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Cellosaurus SAS (CVCL_1675)

[Text version]

Cell line name SAS
Accession CVCL_1675
Resource Identification Initiative To cite this cell line use: SAS (RRID:CVCL_1675)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 33 hours (PubMed=24627082); ~30 hours (lot 07312007), ~21 hours (lot 08022016) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Oral cavity; tongue.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Homozygous (Cosmic-CLP; DepMap).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*24
HLA-BB*52:01
HLA-CC*12:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.4
Native American0
East Asian, North79.62
East Asian, South16.48
South Asian1.04
European, North0
European, South1.46
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_R859 (SAS-H1)CVCL_R860 (SAS-L1)CVCL_A8GP (SAS-R)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; JCRB; RCB; TKG

Markers:
AmelogeninX
CSF1PO11
D3S135816,17
D5S8189
D7S82011,12
D8S117911,13
D13S31710,12
D16S53912,13
D18S5115
D21S1130
FGA24
Penta D10,13
Penta E5,20
TH016,7
TPOX11,12
vWA10,14 (Cosmic-CLP)
10,14,17 (JCRB)
14,17 (DepMap; RCB; TKG)

Run an STR similarity search on this cell line
Publications

DOI=10.11277/stomatology1952.38.20
Takahashi K., Kanazawa H., Akiyama Y., Tazaki S., Takahara M., Muto T., Tanzawa H., Sato K.-I.
Establishment and characterization of a cell line (SAS) from poorly differentiated human squamous cell carcinoma of the tongue.
J. Jpn. Stomatol. Soc. 38:20-28(1989)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M., Itoh K.
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

DOI=10.5843/jsot.13.Suppliment_301
Tadateru A., Tarou I., Tachikawa T.
Establishment and charactalization of human oral squamous cell carcinoma cell line with highly lymph node metastatic potential.
J. Jpn. Soc. Oral Oncol. 13 Suppl. 1:301-306(2001)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-I., Nose M., Miki T., Hamakawa H.
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24627082; DOI=10.3892/ijo.2014.2332
Fujinaga T., Kumamaru W., Sugiura T., Kobayashi Y., Ohyama Y., Ikari T., Onimaru M., Akimoto N., Jogo R., Mori Y.
Biological characterization and analysis of metastasis-related genes in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the mandibular gingiva.
Int. J. Oncol. 44:1614-1624(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0260
RCB; RCB1974
TKG; TKG 0470
Cell line databases/resources CLO; CLO_0051568
Cell_Model_Passport; SIDM00351
Cosmic-CLP; 909708
DepMap; ACH-002029
LINCS_LDP; LCL-1221
Anatomy/cell type resources BTO; BTO:0003981
Biological sample resources BioSample; SAMN03471668
BioSample; SAMN03472049
Chemistry resources ChEMBL-Cells; CHEMBL3308781
ChEMBL-Targets; CHEMBL1075569
GDSC; 909708
PharmacoDB; SAS_1345_2019
Encyclopedic resources Wikidata; Q54952119
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827230
GEO; GSM850387
GEO; GSM950309
GEO; GSM950310
GEO; GSM950311
GEO; GSM950312
GEO; GSM1670402
Polymorphism and mutation databases Cosmic; 909708
Cosmic; 1042300
Cosmic; 1118787
Cosmic; 1120705
Cosmic; 1571803
Cosmic; 2546833
IARC_TP53; 23803
Progenetix; CVCL_1675
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number30