ID   SAS
AC   CVCL_1675
DR   BTO; BTO:0003981
DR   CLO; CLO_0051568
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471668
DR   BioSample; SAMN03472049
DR   Cell_Model_Passport; SIDM00351
DR   ChEMBL-Cells; CHEMBL3308781
DR   ChEMBL-Targets; CHEMBL1075569
DR   Cosmic; 909708
DR   Cosmic; 1042300
DR   Cosmic; 1118787
DR   Cosmic; 1120705
DR   Cosmic; 1571803
DR   Cosmic; 2546833
DR   Cosmic-CLP; 909708
DR   DepMap; ACH-002029
DR   EGA; EGAS00001000978
DR   GDSC; 909708
DR   GEO; GSM827230
DR   GEO; GSM850387
DR   GEO; GSM950309
DR   GEO; GSM950310
DR   GEO; GSM950311
DR   GEO; GSM950312
DR   GEO; GSM1670402
DR   IARC_TP53; 23803
DR   JCRB; JCRB0260
DR   LINCS_LDP; LCL-1221
DR   PharmacoDB; SAS_1345_2019
DR   Progenetix; CVCL_1675
DR   RCB; RCB1974
DR   TKG; TKG 0470
DR   Wikidata; Q54952119
RX   DOI=10.5843/jsot.13.Suppliment_301;
RX   DOI=10.11277/stomatology1952.38.20;
RX   PubMed=9023415;
RX   PubMed=9178645;
RX   PubMed=9290701;
RX   PubMed=17325662;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=24627082;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 33 hours (PubMed=24627082); ~30 hours (lot 07312007), ~21 hours (lot 08022016) (JCRB).
CC   HLA typing: A*24; B*52:01; C*12:02 (PubMed=9178645).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Homozygous (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=1.4%; Native American=0%; East Asian, North=79.62%; East Asian, South=16.48%; South Asian=1.04%; European, North=0%; European, South=1.46% (PubMed=30894373).
CC   Derived from sampling site: Oral cavity; tongue.
ST   Source(s): Cosmic-CLP; DepMap; JCRB; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 10,12
ST   D16S539: 12,13
ST   D18S51: 15
ST   D21S11: 30
ST   D3S1358: 16,17
ST   D5S818: 9
ST   D7S820: 11,12
ST   D8S1179: 11,13
ST   FGA: 24
ST   Penta D: 10,13
ST   Penta E: 5,20
ST   TH01: 6,7
ST   TPOX: 11,12
ST   vWA: 10,14 (Cosmic-CLP)
ST   vWA: 10,14,17 (JCRB)
ST   vWA: 14,17 (DepMap; RCB; TKG)
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 16-12-21; Version: 30
//
RX   DOI=10.5843/jsot.13.Suppliment_301;
RA   Tadateru A., Tarou I., Tachikawa T.;
RT   "Establishment and charactalization of human oral squamous cell
RT   carcinoma cell line with highly lymph node metastatic potential.";
RL   J. Jpn. Soc. Oral Oncol. 13 Suppl. 1:301-306(2001).
//
RX   DOI=10.11277/stomatology1952.38.20;
RA   Takahashi K., Kanazawa H., Akiyama Y., Tazaki S., Takahara M.,
RA   Muto T., Tanzawa H., Sato K.-I.;
RT   "Establishment and characterization of a cell line (SAS) from poorly
RT   differentiated human squamous cell carcinoma of the tongue.";
RL   J. Jpn. Stomatol. Soc. 38:20-28(1989).
//
RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.;
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=9178645; DOI=10.1006/cimm.1997.1108;
RA   Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M.,
RA   Itoh K.;
RT   "CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with
RT   hepatocellular carcinoma.";
RL   Cell. Immunol. 177:176-181(1997).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=17325662; DOI=10.1038/sj.onc.1210330;
RA   Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-I., Nose M., Miki T.,
RA   Hamakawa H.;
RT   "Identification of homozygous deletions of tumor suppressor gene FAT
RT   in oral cancer using CGH-array.";
RL   Oncogene 26:5300-5308(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=24627082; DOI=10.3892/ijo.2014.2332;
RA   Fujinaga T., Kumamaru W., Sugiura T., Kobayashi Y., Ohyama Y.,
RA   Ikari T., Onimaru M., Akimoto N., Jogo R., Mori Y.;
RT   "Biological characterization and analysis of metastasis-related genes
RT   in cell lines derived from the primary lesion and lymph node
RT   metastasis of a squamous cell carcinoma arising in the mandibular
RT   gingiva.";
RL   Int. J. Oncol. 44:1614-1624(2014).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//