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Cellosaurus SBC-1 (CVCL_1676)

[Text version]

Cell line name SBC-1
Synonyms SBC1
Accession CVCL_1676
Resource Identification Initiative To cite this cell line use: SBC-1 (RRID:CVCL_1676)
Comments Problematic cell line: Possibly misidentified/contaminated. Shown to be identical to SBC-2 (JCRB web site and STR profile).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 20.4 hours (PubMed=8286010); ~40 hours (lot 11012007) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Lung.
Sequence variations Mutation; HGNC; 2348; CREBBP; Simple; p.Gly48Ter (c.142G>T); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 9884; RB1; Simple; p.Glu112Ter (c.334G>T); Zygosity=Homozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Lys120Ter (c.358A>T); ClinVar=VCV000012363; Zygosity=Homozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.47
East Asian, North73.66
East Asian, South25.87
South Asian0
European, North0
European, South0
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_W531 ! SBC-2 [Human SCLC]
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D5S8189,11
D7S82011,12
D13S31712
D16S5399
TH018,9
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

DOI=10.2482/haigan.22.53
Hiraki S., Miyai M., Seto T., Tamura T., Watanabe Y., Ozawa S., Ikeda H., Nakata Y., Ohnoshi T., Kimura I.
Establishment of human continuous cell lines from squamous cell, adeno- and small cell carcinoma of the lung and the results of heterotransplantation.
Nihon Haigan Gakkai 22:53-58(1982)

CLPUB00132
Kishimoto N., Ohnoshi T., Hiraki S., Miyake K., Ozawa S., Tamura T., Numata K., Kawahara N., Tamura R., Miyamoto H., Nishii K., Kimura I.
Establishment and characterization of five cell lines from human small cell carcinoma of the lung.
Nihon Haigan Gakkai 24:644-644(1984)

PubMed=2540905
Takahashi T., Obata Y., Sekido Y., Hida T., Ueda R., Watanabe H., Ariyoshi Y., Sugiura T., Takahashi T.
Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics.
Cancer Res. 49:2683-2688(1989)

DOI=10.4044/joma1947.104.9-10_905
Kishimoto N.
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques. Part 2. Biological characteristics of five newly established small cell lung cancer cell lines.
Okayama Igakkai Zasshi 104:905-913(1992)

PubMed=8286010
Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9413215
Yamane H., Kiura K., Tabata M., Bessho A., Tsuchida T., Motoda K., Hiraki A., Ueoka H., Harada M.
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y., Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T., Hayashi S., Aozasa K., Kawase I.
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22399608
Tsuchida T., Yamane H., Ochi N., Tabayashi T., Hiraki A., Nogami N., Takigawa N., Kiura K., Tanimoto M.
Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer.
Anticancer Res. 32:887-892(2012)

PubMed=25120651; DOI=10.3892/ol.2014.2234
Suzuki M., Ikeda K., Shiraishi K., Eguchi A., Mori T., Yoshimoto K., Shibata H., Ito T., Baba Y., Baba H.
Aberrant methylation and silencing of IRF8 expression in non-small cell lung cancer.
Oncol. Lett. 8:1025-1030(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0816
JCRB; NIHS0676 - Discontinued
Cell line databases/resources CCLE; SBC1_LUNG
Cell_Model_Passport; SIDM00365
Cosmic-CLP; 713885
DepMap; ACH-002196
LINCS_LDP; LCL-1865
Ontologies BTO; BTO:0005442
Biological sample resources BioSample; SAMN03472514
Chemistry resources ChEMBL-Cells; CHEMBL3308214
ChEMBL-Targets; CHEMBL2366327
GDSC; 713885
PharmacoDB; SBC1_1347_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM986190
GEO; GSM1670404
Other Wikidata; Q54952163
Polymorphism and mutation databases Cosmic; 713885
Cosmic; 1995623
IARC_TP53; 27235
Progenetix; CVCL_1676
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number33