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Cellosaurus SBC-3 (CVCL_1678)

[Text version]

Cell line name SBC-3
Synonyms SBC3
Accession CVCL_1678
Resource Identification Initiative To cite this cell line use: SBC-3 (RRID:CVCL_1678)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 36 hours (PubMed=3012965); 21.6 hours (PubMed=8286010; PubMed=9615743; PubMed=10628341); 14 hours (PubMed=9914787); ~21 hours (lot 09082011), ~30 hours (lots 07262007 and 012699) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.39
East Asian, North77.93
East Asian, South21.68
South Asian0
European, North0
European, South0
Disease Small cell lung carcinoma (NCIt: C4917)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_M841 (SBC-3/ADM)CVCL_M842 (SBC-3/CDDP)CVCL_M843 (SBC-3/DXCL1)
CVCL_W529 (SBC-3/ETP)CVCL_W535 (SBC-3/SN-38)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81812,13
D7S82012,13
D13S31711,12
D16S5399
TH016,7
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

CLPUB00132
Kishimoto N., Ohnoshi T., Hiraki S., Miyake K., Ozawa S., Tamura T., Numata K., Kawahara N., Tamura R., Miyamoto H., Nishii K., Kimura I.
Establishment and characterization of five cell lines from human small cell carcinoma of the lung.
Nihon Haigan Gakkai 24:644-644(1984)

PubMed=3012965; DOI=10.18926/AMO/31923
Miyamoto H.
Establishment and characterization of an adriamycin-resistant subline of human small cell lung cancer cells.
Acta Med. Okayama 40:65-73(1986)

PubMed=3032107
Kimura I., Ohnoshi T., Hiraki S., Miyamoto H.
Establishment of adriamycin-resistant human small-cell lung cancer cells in culture: analysis of the mechanism of resistance and cross-resistance.
Gan To Kagaku Ryoho 14:830-836(1987)

PubMed=2540905
Takahashi T., Obata Y., Sekido Y., Hida T., Ueda R., Watanabe H., Ariyoshi Y., Sugiura T., Takahashi T.
Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics.
Cancer Res. 49:2683-2688(1989)

DOI=10.4044/joma1947.104.9-10_905
Kishimoto N.
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques. Part 2. Biological characteristics of five newly established small cell lung cancer cell lines.
Okayama Igakkai Zasshi 104:905-913(1992)

PubMed=8286010
Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=9227790; DOI=10.18926/AMO/30795
Matsuo K., Kiura K., Ueoka H., Tabata M., Shibayama T., Matsumura T., Takigawa N., Hiraki S., Harada M.
Growth inhibitory effects of antifolates against an adriamycin-resistant human small cell lung cancer cell line.
Acta Med. Okayama 51:121-127(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9413215
Yamane H., Kiura K., Tabata M., Bessho A., Tsuchida T., Motoda K., Hiraki A., Ueoka H., Harada M.
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=9615743
Moritaka T., Kiura K., Ueoka H., Tabata M., Segawa Y., Shibayama T., Takigawa N., Ohnoshi T., Harada M.
Cisplatin-resistant human small cell lung cancer cell line shows collateral sensitivity to vinca alkaloids.
Anticancer Res. 18:927-933(1998)

PubMed=9914787; DOI=10.1111/j.1349-7006.1998.tb00513.x
Nomoto T., Nishio K., Ishida T., Mori M., Saijo N.
Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f.
Jpn. J. Cancer Res. 89:1179-1186(1998)

PubMed=10358721; DOI=10.18926/AMO/31626
Matsushita A., Tabata M., Ueoka H., Kiura K., Shibayama T., Aoe K., Kohara H., Harada M.
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Acta Med. Okayama 53:67-75(1999)

PubMed=10628341
Ikubo S., Takigawa N., Ueoka H., Kiura K., Tabata M., Shibayama T., Chikamori M., Aoe K., Matsushita A., Harada M.
In vitro evaluation of antimicrotubule agents in human small-cell lung cancer cell lines.
Anticancer Res. 19:3985-3988(1999)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9
Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H., Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T., Fujisawa T.
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22399608
Tsuchida T., Yamane H., Ochi N., Tabayashi T., Hiraki A., Nogami N., Takigawa N., Kiura K., Tanimoto M.
Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer.
Anticancer Res. 32:887-892(2012)

PubMed=23066953; DOI=10.1111/cas.12045
Kubo T., Takigawa N., Osawa M., Harada D., Ninomiya T., Ochi N., Ichihara E., Yamane H., Tanimoto M., Kiura K.
Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy.
Cancer Sci. 104:78-84(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0818
Cell line databases/resources CCLE; SBC3_LUNG
Cell_Model_Passport; SIDM00367
CGH-DB; 103-1
CGH-DB; 9049-4
Cosmic-CLP; 753610
DepMap; ACH-002197
GDSC; 753610
LINCS_LDP; LCL-1879
Ontologies EFO; EFO_0002854
Biological sample resources BioSample; SAMN03472515
Chemistry resources ChEMBL-Cells; CHEMBL3307308
ChEMBL-Targets; CHEMBL614146
PharmacoDB; SBC3_1348_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM17313
GEO; GSM827567
GEO; GSM1670405
Other Wikidata; Q54952168
Polymorphism and mutation databases Cosmic; 753610
Cosmic; 889103
Cosmic; 897745
Cosmic; 1066171
Cosmic; 1212200
Cosmic; 1571746
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24