ID   SCC-15
AC   CVCL_1681
SY   SCC 15; SCC15
DR   BTO; BTO:0005102
DR   CLO; CLO_0008966
DR   EFO; EFO_0006482
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1623
DR   BCRJ; 0218
DR   BioSample; SAMN03473152
DR   BioSample; SAMN10988435
DR   cancercelllines; CVCL_1681
DR   Cell_Model_Passport; SIDM01083
DR   ChEMBL-Cells; CHEMBL3307438
DR   ChEMBL-Targets; CHEMBL614899
DR   Cosmic; 910911
DR   Cosmic; 921835
DR   Cosmic; 932150
DR   Cosmic; 1006468
DR   Cosmic; 1017794
DR   Cosmic; 1041675
DR   Cosmic; 1530752
DR   Cosmic; 1752765
DR   Cosmic; 2131855
DR   Cosmic; 2266793
DR   Cosmic; 2296301
DR   Cosmic-CLP; 910911
DR   DepMap; ACH-000254
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 910911
DR   GEO; GSM422871
DR   GEO; GSM423674
DR   GEO; GSM887558
DR   GEO; GSM888641
DR   GEO; GSM950313
DR   GEO; GSM950314
DR   GEO; GSM950315
DR   GEO; GSM950316
DR   GEO; GSM1670408
DR   IGRhCellID; SCC15%20GSE9585
DR   LiGeA; CCLE_118
DR   LINCS_LDP; LCL-1222
DR   PharmacoDB; SCC15_1352_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1681
DR   PubChem_Cell_line; CVCL_1681
DR   TOKU-E; 3096
DR   Wikidata; Q54952338
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1394225;
RX   PubMed=3138611;
RX   PubMed=6186388;
RX   PubMed=6201865;
RX   PubMed=7214336;
RX   PubMed=8390283;
RX   PubMed=17312569;
RX   PubMed=20014447;
RX   PubMed=20215515;
RX   PubMed=21868764;
RX   PubMed=22460905;
RX   PubMed=22546478;
RX   PubMed=25275298;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=27664486;
RX   PubMed=28196595;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31395879;
RX   PubMed=35839778;
WW   https://tcpaportal.org/mclp/
WW   https://www.atcc.org/en/support/technical-support/faqs/normal-growth-and-morphology-atcc-crl-1623
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Part of: TCGA-110-CL cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 1.5-1.7 days (PubMed=6201865); 1.93 + 0.19 days (PubMed=27664486).
CC   HLA typing: A*01:01,01:01; B*08:01,51:01; C*07:01,14:02; DQA1*04:01,04:01; DQB1*04:02,04:02; DRB1*03:01,08:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=2.32%; East Asian, South=0%; South Asian=0%; European, North=67.04%; European, South=30.64% (PubMed=30894373).
CC   Discontinued: BCRJ; 0218; probable.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): ATCC; Cosmic-CLP; PubMed=21868764; PubMed=25275298; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,13
ST   D13S317: 9,14
ST   D16S539: 12,15
ST   D18S51: 16
ST   D21S11: 30 (PubMed=25877200)
ST   D21S11: 30,31.2 (PubMed=25275298)
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 10,11
ST   D8S1179: 10,13
ST   FGA: 19,24
ST   Penta D: 9 (PubMed=25877200)
ST   Penta D: 9,13 (PubMed=25275298)
ST   Penta E: 7,13
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 43
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
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//
RX   PubMed=1394225;
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RA   Casey G.;
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//
RX   PubMed=3138611; DOI=10.1177/019459988809800603;
RA   Wustrow T.P.U., Raffael A., Valet G.K.;
RT   "Multiparametric flow cytometry of human squamous cell carcinoma lines
RT   from the head and neck.";
RL   Otolaryngol. Head Neck Surg. 98:552-557(1988).
//
RX   PubMed=6186388; DOI=10.1016/0092-8674(82)90324-5;
RA   Wu Y.-J., Parker L.M., Binder N.E., Beckett M.A., Sinard J.H.,
RA   Griffiths C.T., Rheinwald J.G.;
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RT   identified in cultured mesothelial cells and nonkeratinizing
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//
RX   PubMed=6201865; DOI=10.1073/pnas.81.9.2873;
RA   Frei E. III, Rosowsky A., Wright J.E., Cucchi C.A., Lippke J.A.,
RA   Ervin T.J., Jolivet J., Haseltine W.A.;
RT   "Development of methotrexate resistance in a human squamous cell
RT   carcinoma of the head and neck in culture.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:2873-2877(1984).
//
RX   PubMed=7214336;
RA   Rheinwald J.G., Beckett M.A.;
RT   "Tumorigenic keratinocyte lines requiring anchorage and fibroblast
RT   support cultured from human squamous cell carcinomas.";
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//
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RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
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//
RX   PubMed=20014447; DOI=10.1002/hed.21311;
RA   Tsui I.F.L., Garnis C.;
RT   "Integrative molecular characterization of head and neck cancer cell
RT   model genomes.";
RL   Head Neck 32:1143-1160(2010).
//
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RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
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RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
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RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028;
RA   Degen M., Natarajan E., Barron P., Widlund H.R., Rheinwald J.G.;
RT   "MAPK/ERK-dependent translation factor hyperactivation and
RT   dysregulated laminin gamma2 expression in oral dysplasia and squamous
RT   cell carcinoma.";
RL   Am. J. Pathol. 180:2462-2478(2012).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417;
RA   Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y.,
RA   Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.;
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=27664486; DOI=10.1016/j.arcmed.2016.07.007;
RA   Gavish A., Krayzler E., Nagler R.;
RT   "Tumor growth and cell proliferation rate in human oral cancer.";
RL   Arch. Med. Res. 47:271-274(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
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RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
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RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2;
RA   Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M.,
RA   van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.;
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574.1-3574.11(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//