Cellosaurus SCC-4 (CVCL_1684)

Cell line name SCC-4
Synonyms SCC 4; SCC4
Accession CVCL_1684
Resource Identification Initiative To cite this cell line use: SCC-4 (RRID:CVCL_1684)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~60-70 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO11
D13S31711,13
D16S53912
D5S81813
D7S8209,11
TH019.3
TPOX8
vWA15,17
Publications

PubMed=7214336
Rheinwald J.G., Beckett M.A.
Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.
Cancer Res. 41:1657-1663(1981)

PubMed=6722007; DOI=10.1038/bjc.1984.94
Weichselbaum R.R., Dahlberg W., Little J.B., Ervin T.J., Miller D., Hellman S., Rheinwald J.G.
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Br. J. Cancer 49:595-601(1984)

PubMed=3458227; DOI=10.1073/pnas.83.8.2684
Weichselbaum R.R., Dahlberg W., Beckett M.A., Karrison T., Miller D., Clark J., Ervin T.J.
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0
Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.
Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=20145189; DOI=10.1158/1940-6207.CAPR-09-0076
Chakravarti N., Kadara H., Yoon D.-J., Shay J.W., Myers J.N., Lotan D., Sonenberg N., Lotan R.
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.
Cancer Prev. Res. (Philadelphia) 3:331-338(2010)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22006338; DOI=10.1073/pnas.1114669108
Wang N.J., Sanborn Z., Arnett K.L., Bayston L.J., Liao W., Proby C.M., Leigh I.M., Collisson E.A., Gordon P.B., Jakkula L.R., Pennypacker S., Zou Y., Sharma M., North J.P., Vemula S.S., Mauro T.M., Neuhaus I.M., Leboit P.E., Hur J.S., Park K., Huh N., Kwok P.Y., Arron S.T., Massion P.P., Bale A.E., Haussler D., Cleaver J.E., Gray J.W., Spellman P.T., South A.P., Aster J.C., Blacklow S.C., Cho R.J.
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Proc. Natl. Acad. Sci. U.S.A. 108:17761-17766(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24825747; DOI=10.1530/ERC-14-0102
Chang Y.-L., Hsu Y.-K., Wu T.-F., Huang C.-M., Liou L.-Y., Chiu Y.-W., Hsiao Y.-H., Luo F.-J., Yuan T.-C.
Regulation of estrogen receptor alpha function in oral squamous cell carcinoma cells by FAK signaling.
Endocr. Relat. Cancer 21:555-565(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-1624
BCRC; 60142
BCRJ; 0195
DSMZ; ACC-618
ECACC; 89062002
JCRB; JCRB9118
RCB; RCB0745 - Discontinued
Cell line databases/resources CCLE; SCC4_UPPER_AERODIGESTIVE_TRACT
Cosmic-CLP; 910904
GDSC; 910904
IGRhCellID; SCC4%20GSE9585
LINCS_LDP; LCL-1224
Ontologies BTO; BTO:0003775
CLO; CLO_0008968
Biological sample resources BioSample; SAMN01821596
BioSample; SAMN01821663
BioSample; SAMN03471408
Chemistry resources ChEMBL-Cells; CHEMBL3308803
ChEMBL-Targets; CHEMBL1075570
Gene expression databases GEO; GSM422869
GEO; GSM827188
GEO; GSM887560
GEO; GSM888643
GEO; GSM1374865
GEO; GSM1670411
Polymorphism and mutation databases Cosmic; 910904
Cosmic; 921833
Cosmic; 1118794
Cosmic; 1339920
Cosmic; 1608861
Cosmic; 1752767
Cosmic; 2266792
Cosmic; 2513910