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Cellosaurus SCH (CVCL_1687)

[Text version]

Cell line name SCH
Accession CVCL_1687
Resource Identification Initiative To cite this cell line use: SCH (RRID:CVCL_1687)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 54 hours (CelloPub=CLPUB00142); ~1.5 days (lot 07022010) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North77.74
East Asian, South22.24
South Asian0.01
European, North0
European, South0
Disease Gastric choriocarcinoma (NCIt: C95749)
Derived from metastatic site: Omentum.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811
D7S82010,11
D13S31711,12
D16S5399
TH016,7
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=1170940
Kameya T., Kuramoto H., Suzuki K., Kenjo T., Oshikiri T., Hayashi H., Itakura M.
A human gastric choriocarcinoma cell line with human chorionic gonadotropin and placental alkaline phosphatase production.
Cancer Res. 35:2025-2032(1975)

CLPUB00142
Tanaka K., Takeuchi S.
Cell culture of choriocarcinoma.
Tissue Cult. 6:471-478(1980)

PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4
Sekiya S., Kaiho T., Shirotake S., Iwasawa H., Takeda B., Takamizawa H.
Effect of methotrexate on the growth and human chorionic gonadotropin secretion of human choriocarcinoma cell lines in vitro.
Am. J. Obstet. Gynecol. 146:57-64(1983)

PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Int. J. Gynecol. Obstet. 24:301-307(1986)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

DOI=10.1007/0-306-46861-1_8
Ganapathy V., Prasad P.D., Leibach F.H.
Choriocarcinoma.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999)

PubMed=11014955; DOI=10.1159/000010310
Takayanagi T., Aoki Y., Tanaka K.
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Gynecol. Obstet. Invest. 50:198-202(2000)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0251
Cell line databases/resources CCLE; SCH_STOMACH
Cell_Model_Passport; SIDM00383
Cosmic-CLP; 909711
DepMap; ACH-002198
LINCS_LDP; LCL-1148
Ontologies EFO; EFO_0002856
Biological sample resources BioSample; SAMN03471666
Chemistry resources ChEMBL-Cells; CHEMBL3308783
ChEMBL-Targets; CHEMBL1075573
GDSC; 909711
PharmacoDB; SCH_1359_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM552371
GEO; GSM562417
GEO; GSM827269
GEO; GSM1670414
Other Wikidata; Q54952424
Polymorphism and mutation databases Cosmic; 801343
Cosmic; 909711
Cosmic; 1187290
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2019
Version number27