Cellosaurus SCH (CVCL_1687)

Cell line name SCH
Accession CVCL_1687
Resource Identification Initiative To cite this cell line use: SCH (RRID:CVCL_1687)
Comments Part of: COSMIC cell lines project.
Doubling time: ~1.5 days (lot 07022010) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Gastric choriocarcinoma (NCIt: C95749)
Derived from metastatic site: Omentum.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO10,11
D13S31711,12
D16S5399
D5S81811
D7S82010,11
TH016,7
TPOX11
vWA17
Publications

PubMed=1170940
Kameya T., Kuramoto H., Suzuki K., Kenjo T., Oshikiri T., Hayashi H., Itakura M.
A human gastric choriocarcinoma cell line with human chorionic gonadotropin and placental alkaline phosphatase production.
Cancer Res. 35:2025-2032(1975)

PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4
Sekiya S., Kaiho T., Shirotake S., Iwasawa H., Takeda B., Takamizawa H.
Effect of methotrexate on the growth and human chorionic gonadotropin secretion of human choriocarcinoma cell lines in vitro.
Am. J. Obstet. Gynecol. 146:57-64(1983)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11014955; DOI=10.1159/000010310
Takayanagi T., Aoki Y., Tanaka K.
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Gynecol. Obstet. Invest. 50:198-202(2000)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0251
Cell line databases/resources Cosmic-CLP; 909711
GDSC; 909711
LINCS_LDP; LCL-1148
Ontologies EFO; EFO_0002856
Biological sample resources BioSample; SAMN03471666
Chemistry resources ChEMBL-Cells; CHEMBL3308783
ChEMBL-Targets; CHEMBL1075573
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM552371
GEO; GSM562417
GEO; GSM827269
GEO; GSM1670414
Other Wikidata; Q54952424
Polymorphism and mutation databases Cosmic; 801343
Cosmic; 909711
Cosmic; 1187290