Cellosaurus SIG-M5 (CVCL_1694)

Cell line name SIG-M5
Synonyms SigM5; SIGM5
Accession CVCL_1694
Resource Identification Initiative To cite this cell line use: SIG-M5 (RRID:CVCL_1694)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~72 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Homozygous for JAK2 p.Val617Phe (PubMed=16408098).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S31711,12
D16S53911,12
D18S5115,16,18
D21S1129,32.2
D3S135818
D5S81811,13
D7S8209,11 (Cosmic-CLP; PubMed=25877200)
9 (DSMZ)
D8S117914,16
FGA22,26
Penta D10,13
Penta E7,19
TH017,9.3
TPOX8,11
vWA17,19
Publications

PubMed=10848831; DOI=10.1046/j.1365-2141.2000.02013.x
Walter R., Schoedon G., Bachli E., Betts D.R., Hossle J.P., Calandra T., Joller-Jemelka H.I., Fehr J., Schaffner A.
Establishment and characterization of an arsenic-sensitive monoblastic leukaemia cell line (SigM5).
Br. J. Haematol. 109:396-404(2000)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-468
Cell line databases/resources CCLE; SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 909715
GDSC; 909715
LINCS_LDP; LCL-1071
Ontologies CLO; CLO_0009016
EFO; EFO_0006751
Biological sample resources BioSample; SAMN03473111
BioSample; SAMN03473559
Chemistry resources ChEMBL-Cells; CHEMBL3308248
ChEMBL-Targets; CHEMBL2366251
Gene expression databases GEO; GSM887571
GEO; GSM888654
GEO; GSM1374871
GEO; GSM1670421
Polymorphism and mutation databases Cosmic; 787476
Cosmic; 975299
Cosmic; 909715
Cosmic; 1012117
Cosmic; 1281352
Cosmic; 1465968
Cosmic; 2131558
Cosmic; 2306238