Cellosaurus SK-N-DZ (CVCL_1701)

Cell line name SK-N-DZ
Synonyms SKNDZ
Accession CVCL_1701
Resource Identification Initiative To cite this cell line use: SK-N-DZ (RRID:CVCL_1701)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
From: Memorial Sloan-Kettering Cancer Center; New York; USA.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S3178,11
D16S5399,11
D18S5115,17
D21S1129,31
D3S135817
D5S81812
D7S82012,13
D8S117912,13
FGA18,22
Penta D9,14
Penta E7,10
TH016,9
TPOX8
vWA16,18
Publications

DOI=10.1159/00040702
Helson L., Verma M., Helson C.
Vitamin E and human neuroblastoma.
(In) Modulation and mediation of cancer by vitamins; Meyskens F.L., Prasad K.N. (eds.); pp.258-265; Karger; Basel (1983)

PubMed=2987426; DOI=10.1007/BF00165170
Helson L., Helson C.
Human neuroblastoma cells and 13-cis-retinoic acid.
J. Neurooncol. 3:39-41(1985)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line collections ATCC; CRL-2149
ECACC; 94092305
Cell line databases/resources CLDB; cl4335
CCLE; SKNDZ_AUTONOMIC_GANGLIA
CGH-DB; 77-1
CGH-DB; 9094-4
Cosmic-CLP; 688086
GDSC; 688086
IGRhCellID; SKNDZ
LINCS_LDP; LCL-1970
Lonza; 1190
Ontologies BTO; BTO:0004217
CLO; CLO_0009054
EFO; EFO_0005721
Biological sample resources BioSample; SAMN03473093
ENCODE; ENCBS373BOT
ENCODE; ENCBS439FDS
ENCODE; ENCBS478IFE
ENCODE; ENCBS514GVM
ENCODE; ENCBS520AAA
ENCODE; ENCBS521AAA
ENCODE; ENCBS580YYW
ENCODE; ENCBS707BMT
ENCODE; ENCBS715HTH
ENCODE; ENCBS773LCT
ENCODE; ENCBS893THB
Chemistry resources ChEMBL-Cells; CHEMBL3308474
ChEMBL-Targets; CHEMBL1075579
Gene expression databases GEO; GSM887594
GEO; GSM888677
GEO; GSM1366412
GEO; GSM1670451
GEO; GSM2371257
GEO; GSM2394372
Polymorphism and mutation databases Cosmic; 688086
Cosmic; 897447
Cosmic; 930076
Cosmic; 1019931
Cosmic; 1109370
Cosmic; 1162004
Cosmic; 1167415
Cosmic; 2058115
Cosmic; 2485951