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Cellosaurus SKG-IIIa (CVCL_1704)

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Cell line name SKG-IIIa
Accession CVCL_1704
Resource Identification Initiative To cite this cell line use: SKG-IIIa (RRID:CVCL_1704)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Uterus; cervix.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Lys132Asn (c.396G>C); ClinVar=VCV000376624; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North84.88
East Asian, South14.94
South Asian0
European, North0
European, South0
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2795 ! SKG-IIIb
Sex of cell Female
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; RCB; TKG

D7S82010 (JCRB)
10,12 (Cosmic-CLP; PubMed=25877200; RCB; TKG)
Penta D9
Penta E10

Run an STR similarity search on this cell line

Nozawa S., Udagawa Y., Ohta H., Kurihara S., Fishman W.H.
Newly established uterine cervical cancer cell line (SKG-III) with Regan isoenzyme, human chorionic gonadotropin beta-subunit, and pregnancy-specific beta 1-glycoprotein phenotypes.
Cancer Res. 43:1748-1760(1983)

Udagawa Y., Nozawa S., Tsukazaki K., Ohta H., Akiba T., Kurihara S.
Biological properties of two newly established cell lines (SKG-3a,3b) from a human uterine cervical epidermoid carcinoma.
Nihon Sanka Fujinka Gakkai Zasshi 36:237-246(1984)

PubMed=8380785; DOI=10.1006/gyno.1993.1016
Iwasaka T., Oh-uchida M., Matsuo N., Yokoyama M., Fukuda K., Hara K., Fukuyama K., Hori K., Sugimori H.
Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines.
Gynecol. Oncol. 48:104-109(1993)

Kuno H., Yoshida T.
Detection of human papillomavirus types 16, 18, and 33 in cell lines derived from human genital organs by polymerase chain reaction.
Res. Commun. Inst. Ferment. Osaka 18:6-12(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15099960; DOI=10.1016/j.ygyno.2004.02.012
Fujimoto T., Nishikawa A., Iwasaki M., Akutagawa N., Teramoto M., Kudo R.
Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array.
Gynecol. Oncol. 93:446-453(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; IFO50310
RCB; RCB1892
TKG; TKG 0462
Cell line databases/resources CCLE; SKGIIIA_CERVIX
Cell_Model_Passport; SIDM00381
Cosmic-CLP; 930298
DepMap; ACH-002020
Ontologies CLO; CLO_0050923
Biological sample resources BioSample; SAMN01821739
BioSample; SAMN03470894
BioSample; SAMN03471660
Chemistry resources ChEMBL-Cells; CHEMBL3308786
ChEMBL-Targets; CHEMBL1075581
GDSC; 930298
PharmacoDB; SKGIIIa_1417_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670429
Other Wikidata; Q54954734
Polymorphism and mutation databases Cosmic; 877461
Cosmic; 930298
Cosmic; 1152539
Cosmic; 1995630
IARC_TP53; 27576
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number30