Cellosaurus SNU-C2B (CVCL_1710)

Cell line name SNU-C2B
Synonyms SNUC2B; NCI-SNU-C2B
Accession CVCL_1710
Resource Identification Initiative To cite this cell line use: SNU-C2B (RRID:CVCL_1710)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Seoul National University (SNU) cell line collection.
Microsatellite instability: Instable (MSI-high) (PubMed=2592653; Sanger).
Sequence variation: Heterozygous for TP53 p.Arg273Cys and p.Arg273His (PubMed=16418264).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Disease Cecum adenocarcinoma (NCIt: C5543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1709 ! SNU-C2A
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC; KCLB

Markers:
AmelogeninX
CSF1PO11,13,14 (ATCC)
11,14 (Cosmic-CLP; ECACC; KCLB)
D13S3179,10,11 (ATCC; Cosmic-CLP)
9,10 (ECACC; KCLB)
D16S5398,9
D3S135813
D5S8188,9
D7S82013,16 (ATCC; Cosmic-CLP; KCLB)
12,13 (ECACC)
FGA20,23
TH019
TPOX8
vWA15,18,19 (ATCC; Cosmic-CLP)
15,19 (ECACC)
15,18 (KCLB)
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

DOI=10.1101/092767
Roumeliotis T.I., Williams S.P., Goncalves E., Zamanzad G.F., Aben N., Michaut M., Schubert M., Wright J.C., Yang M., Alsinet C., Dienstmann R., Guinney J., Beltrao P., Brazma A., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
bioRxiv 2016:092767-092767(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CCL-250
ECACC; 96020932
KCLB; 0000C2B
Cell line databases/resources ColonAtlas; SNUC2B
Cosmic-CLP; 909740
GDSC; 909740
LINCS_LDP; LCL-1341
Ontologies CLO; CLO_0009105
Biological sample resources BioSample; SAMN03471381
Chemistry resources ChEMBL-Cells; CHEMBL3308279
ChEMBL-Targets; CHEMBL2366279
Gene expression databases GEO; GSM741262
GEO; GSM1346856
GEO; GSM1374902
GEO; GSM1448087
GEO; GSM1670477
Polymorphism and mutation databases Cosmic; 687541
Cosmic; 909740
Cosmic; 1218880
Cosmic; 1312311
Cosmic; 1479583
Cosmic; 1995644
Cosmic; 2302010