ID   SR
AC   CVCL_1711
AS   CVCL_2203
SY   SR-786; SR786
DR   BTO; BTO:0003585
DR   CLO; CLO_0009126
DR   CLO; CLO_0009129
DR   EFO; EFO_0002352
DR   EFO; EFO_0006491
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   ATCC; CRL-2262
DR   BioSample; SAMN03471620
DR   BioSample; SAMN03473321
DR   BioSample; SAMN10988434
DR   cancercelllines; CVCL_1711
DR   Cell_Model_Passport; SIDM00096
DR   ChEMBL-Cells; CHEMBL3307586
DR   ChEMBL-Targets; CHEMBL614300
DR   Cosmic; 687852
DR   Cosmic; 850201
DR   Cosmic; 875868
DR   Cosmic; 897453
DR   Cosmic; 905965
DR   Cosmic; 974254
DR   Cosmic; 1086366
DR   Cosmic; 1044251
DR   Cosmic; 1092639
DR   Cosmic; 1305341
DR   Cosmic; 1312327
DR   Cosmic; 1998482
DR   Cosmic; 2060807
DR   Cosmic; 2674497
DR   Cosmic-CLP; 905965
DR   DepMap; ACH-000338
DR   DepMap; ACH-001665
DR   DSMZ; ACC-369
DR   DSMZCellDive; ACC-369
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 905965
DR   GEO; GSM2102
DR   GEO; GSM50199
DR   GEO; GSM50911
DR   GEO; GSM743462
DR   GEO; GSM750815
DR   GEO; GSM799350
DR   GEO; GSM799413
DR   GEO; GSM827416
DR   GEO; GSM887648
DR   GEO; GSM888740
DR   GEO; GSM1153420
DR   GEO; GSM1178626
DR   GEO; GSM1178627
DR   GEO; GSM1178628
DR   GEO; GSM1181290
DR   GEO; GSM1181362
DR   GEO; GSM1670479
DR   GEO; GSM2124688
DR   IARC_TP53; 21092
DR   IARC_TP53; 28377
DR   IGRhCellID; SR
DR   LiGeA; CCLE_367
DR   LINCS_LDP; LCL-1129
DR   NCI-DTP; SR
DR   PharmacoDB; SR_1495_2019
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1711
DR   PubChem_Cell_line; CVCL_1711
DR   SKY/M-FISH/CGH; 2805
DR   Wikidata; Q54955622
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2313723;
RX   PubMed=2041050;
RX   PubMed=2456698;
RX   PubMed=8558920;
RX   PubMed=9787181;
RX   PubMed=10700174;
RX   PubMed=15356658;
RX   PubMed=15748285;
RX   PubMed=17088437;
RX   PubMed=19372543;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22068913;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22460905;
RX   PubMed=22628656;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24279929;
RX   PubMed=24670534;
RX   PubMed=25355872;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=28196595;
RX   PubMed=29899875;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=35839778;
WW   https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=34
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI-60 cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: ~30 hours (DSMZ=ACC-369); 28.7 hours (NCI-DTP=SR).
CC   HLA typing: A*02,03; B*37:01,39:01; C*06:02,12:03:01; DPB1*04:01; DQB1*05:01:01,05:02:01; DRB1*01,16:01:01 (PubMed=15748285).
CC   HLA typing: A*02:01,03:01; B*37:01,39:01; C*06:02,12:03; DQA1*01:01,01:01; DQB1*05:02,05:02; DRB1*01:01,16:01 (PubMed=26589293).
CC   HLA typing: A*02:01:01,03:01:01; B*37:01:01,39:01:01; C*06:02:01,12:03:01; DPA1*01:03:01,01:03:01; DPB1*04:01:01,04:01:01; DQA1*01:02:02,01:01:01; DQB1*05:01:01,05:02:01; DRA*01:01:01,01:01:01; DRB1*01:01:01,16:01:01 (DSMZCellDive=ACC-369).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; 427; ALK + HGNC; 7910; NPM1; Name(s)=NPM1-ALK (PubMed=25485619; PubMed=29899875).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Fluorescence phenotype profiling.
CC   Omics: lncRNA expression profiling.
CC   Omics: Metabolome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Virome analysis using RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=3.12%; East Asian, South=0%; South Asian=0%; European, North=62.78%; European, South=34.1% (PubMed=30894373).
CC   Discontinued: DepMap; ACH-001665; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=19372543; PubMed=25877200
ST   Amelogenin: X (DSMZ)
ST   Amelogenin: X,Y (ATCC; Cosmic-CLP; PubMed=19372543; PubMed=25877200)
ST   CSF1PO: 14,15
ST   D13S317: 11 (ATCC; Cosmic-CLP; PubMed=19372543; PubMed=25877200)
ST   D13S317: 11,13 (DSMZ)
ST   D16S539: 11 (Cosmic-CLP)
ST   D16S539: 11,13 (ATCC; DSMZ; PubMed=19372543; PubMed=25877200)
ST   D18S51: 13,14 (PubMed=19372543; PubMed=25877200)
ST   D18S51: 14 (DSMZ)
ST   D19S433: 12,14
ST   D21S11: 28,30
ST   D2S1338: 24
ST   D3S1358: 14,16
ST   D5S818: 11
ST   D7S820: 9,12
ST   D8S1179: 13
ST   FGA: 20,22
ST   Penta D: 9,13
ST   Penta E: 11,12
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C37193; Anaplastic large cell lymphoma, ALK-positive
DI   ORDO; Orphanet_300895; ALK-positive anaplastic large cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 42
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
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//
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RA   Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L.,
RA   Morse H.C. III, Stroncek D., Marincola F.M.;
RT   "HLA class I and II genotype of the NCI-60 cell lines.";
RL   J. Transl. Med. 3:11.1-11.8(2005).
//
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RA   Ikediobi O.N., Davies H., Bignell G.R., Edkins S., Stevens C.,
RA   O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L.,
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RA   Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R.;
RT   "Mutation analysis of 24 known cancer genes in the NCI-60 cell line
RT   set.";
RL   Mol. Cancer Ther. 5:2606-2612(2006).
//
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RA   Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y.,
RA   Chanock S.J., Weinstein J.N.;
RT   "DNA fingerprinting of the NCI-60 cell line panel.";
RL   Mol. Cancer Ther. 8:713-724(2009).
//
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RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
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RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
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RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
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RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
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RA   Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J.,
RA   Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V.,
RA   Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R.,
RA   Ambudkar S.V., Gottesman M.M.;
RT   "Redefining the relevance of established cancer cell lines to the
RT   study of mechanisms of clinical anti-cancer drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011).
//
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RA   Ruan X.-Y., Kocher J.-P.A., Pommier Y., Liu H.-F., Reinhold W.C.;
RT   "Mass homozygotes accumulation in the NCI-60 cancer cell lines as
RT   compared to HapMap trios, and relation to fragile site location.";
RL   PLoS ONE 7:E31628-E31628(2012).
//
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RA   Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H.,
RA   Yoon C.N., Chang Y.-T.;
RT   "Identification of cancer cell-line origins using fluorescence
RT   image-based phenomic screening.";
RL   PLoS ONE 7:E32096-E32096(2012).
//
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RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
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RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
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RA   Kafri R., Kirschner M.W., Clish C.B., Mootha V.K.;
RT   "Metabolite profiling identifies a key role for glycine in rapid
RT   cancer cell proliferation.";
RL   Science 336:1040-1044(2012).
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RT   and systems pharmacology.";
RL   Cancer Res. 73:4372-4382(2013).
//
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RA   Wilhelm M., Kuster B.;
RT   "Global proteome analysis of the NCI-60 cell line panel.";
RL   Cell Rep. 4:609-620(2013).
//
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RA   Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R.,
RA   Hirshfield K.M., Oltvai Z.N., Vazquez A.;
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RT   protein synthesis rates.";
RL   Cancer Metab. 1:20.1-20.13(2013).
//
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RA   Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.;
RT   "High resolution copy number variation data in the NCI-60 cancer cell
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RL   J. Virol. 89:713-729(2015).
//
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RL   Nat. Biotechnol. 33:306-312(2015).
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RL   Genome Med. 7:118.1-118.7(2015).
//
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RL   Sci. Data 3:160052-160052(2016).
//
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//
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RT   panel.";
RL   Mob. DNA 7:20.1-20.11(2016).
//
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RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
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RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29899875; DOI=10.18632/oncotarget.25489;
RA   Krumbholz M., Woessmann W., Zierk J., Seniuk D., Ceppi P.,
RA   Zimmermann M., Singh V.K., Metzler M., Damm-Welk C.;
RT   "Characterization and diagnostic application of genomic NPM-ALK fusion
RT   sequences in anaplastic large-cell lymphoma.";
RL   Oncotarget 9:26543-26555(2018).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
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//
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RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
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