Cellosaurus SUP-T1 (CVCL_1714)

Cell line name SUP-T1
Synonyms Sup-T1; SUPT-1; SupT-1; Sup T-1; SUP T-1; SUP T1; Sup T1; SupT1; SUPT1; Tsup-1; VB; Stanford University Pediatric T-cell line 1
Accession CVCL_1714
Resource Identification Initiative To cite this cell line use: SUP-T1 (RRID:CVCL_1714)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Useful in studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.
Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.
Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ); ~24-36 hours (NIH-ARP).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Derived from sampling site: Pleural effusion.
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1E03 (BC7)CVCL_1H35 (Nef-ER 31)CVCL_X633 (Sup-T1-CCR5)
CVCL_M773 (Sup-T1/JI)CVCL_M772 (SUP-T1/Z29)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ

AmelogeninX,Y (ATCC; Cosmic-CLP)
D13S31711,12 (ATCC; Cosmic-CLP)
10,11,12 (DSMZ)
D16S5399,11,12 (ATCC; Cosmic-CLP)
9,10,11 (DSMZ)
D5S81811,12 (ATCC; Cosmic-CLP)
10,11,12 (DSMZ)
TPOX9 (ATCC; Cosmic-CLP)
8,9 (DSMZ)
vWA16,18 (ATCC; Cosmic-CLP)
16,18,19 (DSMZ)
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0024&theme=default

Smith S.D., Shatsky M., Cohen P.S., Warnke R., Link M.P., Glader B.E.
Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.
Cancer Res. 44:5657-5660(1984)

PubMed=6438800; DOI=10.1126/science.6438800
Hecht F., Morgan R., Hecht B.K., Smith S.D.
Common region on chromosome 14 in T-cell leukemia and lymphoma.
Science 226:1445-1447(1984)

PubMed=3935328; DOI=10.1016/0092-8674(85)90243-0
Baer R., Chen K.-C., Smith S.D., Rabbitts T.H.
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors.
Cell 43:705-713(1985)

Smith S.D., Morgan R., Link M.P., McFall P., Hecht F.
Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell leukemia/lymphoma.
Blood 67:650-656(1986)

PubMed=3010463; DOI=10.1126/science.3010463
Lifson J.D., Reyes G.R., McGrath M.S., Stein B.S., Engleman E.G.
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen.
Science 232:1123-1127(1986)

PubMed=3036367; DOI=10.1016/0092-8674(87)90666-0
Baer R., Forster A., Rabbitts T.H.
The mechanism of chromosome 14 inversion in a human T cell lymphoma.
Cell 50:97-105(1987)

PubMed=3107838; DOI=10.1016/0092-8674(87)90542-3
Stein B.S., Gowda S.D., Lifson J.D., Penhallow R.C., Bensch K.G., Engleman E.G.
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.
Cell 49:659-668(1987)

Stranks G., Height S.E., Mitchell P., Jadayel D., Yuille M.A., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cell line collections ATCC; CRL-1942
BCRC; 60191
ECACC; 95013123
ICLC; HTL96007
NIH-ARP; 100-322
NIH-ARP; 150-147
Cell line databases/resources CLDB; cl4420
CLDB; cl4421
CLDB; cl4422
Cosmic-CLP; 909743
GDSC; 909743
Ontologies BTO; BTO:0003582
CLO; CLO_0009164
Biological sample resources BioSample; SAMN03471266
BioSample; SAMN03473416
Chemistry resources ChEMBL-Cells; CHEMBL3308368
ChEMBL-Targets; CHEMBL614940
Gene expression databases GEO; GSM482493
GEO; GSM887662
GEO; GSM888754
GEO; GSM1670494
Polymorphism and mutation databases Cosmic; 687855
Cosmic; 909743
Cosmic; 1086322
Cosmic; 1281384
Cosmic; 1330493
Cosmic; 1524822
Cosmic; 1664528
Cosmic; 1760532
Cosmic; 2165716
Cosmic; 2602931