AC   CVCL_1714
SY   Sup-T1; SUPT-1; SupT-1; Sup T-1; SUP T-1; SUP T1; Sup T1; SupT1; SUPT1; Tsup-1; VB; Stanford University Pediatric T-cell line 1
DR   BTO; BTO:0003582
DR   CLO; CLO_0009164
DR   CLDB; cl4420
DR   CLDB; cl4421
DR   CLDB; cl4422
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1942
DR   BCRC; 60191
DR   BioSample; SAMN03471266
DR   BioSample; SAMN03473416
DR   BioSample; SAMN10987655
DR   Cell_Model_Passport; SIDM01154
DR   ChEMBL-Cells; CHEMBL3308368
DR   ChEMBL-Targets; CHEMBL614940
DR   Cosmic; 687855
DR   Cosmic; 909743
DR   Cosmic; 1086322
DR   Cosmic; 1281384
DR   Cosmic; 1330493
DR   Cosmic; 1524822
DR   Cosmic; 1664528
DR   Cosmic; 1760532
DR   Cosmic; 2165716
DR   Cosmic; 2602931
DR   Cosmic-CLP; 909743
DR   DepMap; ACH-000953
DR   DSMZ; ACC-140
DR   ECACC; 95013123
DR   GDSC; 909743
DR   GEO; GSM482493
DR   GEO; GSM887662
DR   GEO; GSM888754
DR   GEO; GSM1670494
DR   ICLC; HTL96007
DR   LiGeA; CCLE_331
DR   Lonza; 293
DR   NIH-ARP; 100-322
DR   NIH-ARP; 150-147
DR   Wikidata; Q54970880
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3004618;
RX   PubMed=3010463;
RX   PubMed=3036367;
RX   PubMed=3107838;
RX   PubMed=3935328;
RX   PubMed=6437672;
RX   PubMed=6438800;
RX   PubMed=7849311;
RX   PubMed=8558920;
RX   PubMed=9933131;
RX   PubMed=17170727;
RX   PubMed=20164919;
RX   PubMed=22292511;
RX   PubMed=22460905;
RX   PubMed=22675565;
RX   PubMed=25355872;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Characteristics: Useful in studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.
CC   Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.
CC   Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ); ~24-36 hours (NIH-ARP).
CC   Microsatellite instability: Stable (MSS) (Sanger); Instable (MSI) (PubMed=31068700).
CC   Sequence variation: Heterozygous for EGFR p.Cys251Tyr (c.752G>A) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for KIT p.Arg177His (c.530G>A) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for MET p.Arg191Trp (c.571C>T) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for PIK3CA p.Glu545Asp (c.1635G>T) and p.Glu970Lys (c.2908G>A) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for PTCH1 p.Arg682Cys (c.2044C>T) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for SPRY4 p.Arg48Trp (c.142C>T) (PubMed=22675565; Cosmic-CLP).
CC   Sequence variation: Heterozygous for TP53 p.Arg267Leu (c.800G>T) (PubMed=22675565; Cosmic-CLP).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Omics: Virome analysis using RNAseq.
CC   Genome ancestry: African=0.14%; Native American=1.61%; East Asian, North=0%; East Asian, South=0%; South Asian=9.49%; European, North=46.77%; European, South=41.99% (PubMed=30894373).
CC   Derived from sampling site: Pleural effusion.
ST   Source(s): ATCC; Cosmic-CLP; DSMZ
ST   Amelogenin: X,Y (ATCC; Cosmic-CLP)
ST   Amelogenin: X (DSMZ)
ST   CSF1PO: 10,11
ST   D13S317: 11,12 (ATCC; Cosmic-CLP)
ST   D13S317: 10,11,12 (DSMZ)
ST   D16S539: 9,11,12 (ATCC; Cosmic-CLP)
ST   D16S539: 9,10,11 (DSMZ)
ST   D5S818: 11,12 (ATCC; Cosmic-CLP)
ST   D5S818: 10,11,12 (DSMZ)
ST   D7S820: 11
ST   TH01: 9.3
ST   TPOX: 9 (ATCC; Cosmic-CLP)
ST   TPOX: 8,9 (DSMZ)
ST   vWA: 16,18 (ATCC; Cosmic-CLP)
ST   vWA: 16,18,19 (DSMZ)
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-07-19; Version: 26
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=3004618;
RA   Smith S.D., Morgan R., Link M.P., McFall P., Hecht F.;
RT   "Cytogenetic and immunophenotypic analysis of cell lines established
RT   from patients with T cell leukemia/lymphoma.";
RL   Blood 67:650-656(1986).
RX   PubMed=3010463; DOI=10.1126/science.3010463;
RA   Lifson J.D., Reyes G.R., McGrath M.S., Stein B.S., Engleman E.G.;
RT   "AIDS retrovirus induced cytopathology: giant cell formation and
RT   involvement of CD4 antigen.";
RL   Science 232:1123-1127(1986).
RX   PubMed=3036367; DOI=10.1016/0092-8674(87)90666-0;
RA   Baer R., Forster A., Rabbitts T.H.;
RT   "The mechanism of chromosome 14 inversion in a human T cell
RT   lymphoma.";
RL   Cell 50:97-105(1987).
RX   PubMed=3107838; DOI=10.1016/0092-8674(87)90542-3;
RA   Stein B.S., Gowda S.D., Lifson J.D., Penhallow R.C., Bensch K.G.,
RA   Engleman E.G.;
RT   "pH-independent HIV entry into CD4-positive T cells via virus envelope
RT   fusion to the plasma membrane.";
RL   Cell 49:659-668(1987).
RX   PubMed=3935328; DOI=10.1016/0092-8674(85)90243-0;
RA   Baer R., Chen K.-C., Smith S.D., Rabbitts T.H.;
RT   "Fusion of an immunoglobulin variable gene and a T cell receptor
RT   constant gene in the chromosome 14 inversion associated with T cell
RT   tumors.";
RL   Cell 43:705-713(1985).
RX   PubMed=6437672;
RA   Smith S.D., Shatsky M., Cohen P.S., Warnke R., Link M.P., Glader B.E.;
RT   "Monoclonal antibody and enzymatic profiles of human malignant
RT   T-lymphoid cells and derived cell lines.";
RL   Cancer Res. 44:5657-5660(1984).
RX   PubMed=6438800; DOI=10.1126/science.6438800;
RA   Hecht F., Morgan R., Hecht B.K., Smith S.D.;
RT   "Common region on chromosome 14 in T-cell leukemia and lymphoma.";
RL   Science 226:1445-1447(1984).
RX   PubMed=7849311;
RA   Stranks G., Height S.E., Mitchell P., Jadayel D., Yuille M.A.,
RA   De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L.,
RA   Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D.,
RA   Millar J.L., Catovsky D., Dyer M.J.S.;
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
RX   PubMed=8558920;
RA   Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M.,
RA   Quentmeier H., Drexler H.G.;
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
RX   PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7;
RA   Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.;
RT   "Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines:
RT   suggestion for classification by immunophenotype and T-cell receptor
RT   studies.";
RL   Leuk. Res. 23:19-27(1999).
RX   PubMed=17170727; DOI=10.1038/sj.leu.2404486;
RA   Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M.,
RA   de Vos J., Macleod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M.,
RA   Langerak A.W.;
RT   "Human T-cell lines with well-defined T-cell receptor gene
RT   rearrangements as controls for the BIOMED-2 multiplex polymerase chain
RT   reaction tubes.";
RL   Leukemia 21:230-237(2007).
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
RX   PubMed=22292511; DOI=10.2174/187221512799303172;
RA   Ho P., Dai K.-S., Chen H.-L.;
RT   "Molecular cloning of a novel PPEF-1 gene variant from a T-cell
RT   lymphoblastic lymphoma cell line.";
RL   Recent Pat. DNA Gene Seq. 6:72-77(2012).
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
RX   PubMed=22675565; DOI=10.1371/journal.pone.0038463;
RA   Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E.,
RA   Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G.,
RA   Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P.,
RA   Cools J., Aerts S.;
RT   "High accuracy mutation detection in leukemia on a selected panel of
RT   cancer genes.";
RL   PLoS ONE 7:E38463-E38463(2012).
RX   PubMed=25355872; DOI=10.1128/JVI.02570-14;
RA   Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z.,
RA   O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.;
RT   "High-throughput RNA sequencing-based virome analysis of 50 lymphoma
RT   cell lines from the Cancer Cell Line Encyclopedia project.";
RL   J. Virol. 89:713-729(2015).
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940-940(2018).
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).