ID   SW1710
AC   CVCL_1721
SY   SW-1710; SW 1710
DR   CLO; CLO_0009213
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473594
DR   BioSample; SAMN10988432
DR   cancercelllines; CVCL_1721
DR   Cell_Model_Passport; SIDM00420
DR   ChEMBL-Cells; CHEMBL3308804
DR   ChEMBL-Targets; CHEMBL1075590
DR   Cosmic; 715750
DR   Cosmic; 760483
DR   Cosmic; 845572
DR   Cosmic; 909749
DR   Cosmic; 1016890
DR   Cosmic; 1046685
DR   Cosmic; 1285129
DR   Cosmic; 1285989
DR   Cosmic; 2037957
DR   Cosmic; 2050463
DR   Cosmic; 2057458
DR   Cosmic; 2444251
DR   Cosmic; 2686115
DR   Cosmic-CLP; 909749
DR   DepMap; ACH-000566
DR   DSMZ; ACC-426
DR   DSMZCellDive; ACC-426
DR   EGA; EGAS00001000978
DR   GDSC; 909749
DR   GEO; GSM136258
DR   GEO; GSM763023
DR   GEO; GSM827181
DR   GEO; GSM887670
DR   GEO; GSM888762
DR   GEO; GSM1374921
DR   GEO; GSM1574554
DR   GEO; GSM1670504
DR   IARC_TP53; 6606
DR   LiGeA; CCLE_831
DR   LINCS_LDP; LCL-1719
DR   PharmacoDB; SW1710_1534_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1721
DR   PubChem_Cell_line; CVCL_1721
DR   Wikidata; Q54971090
RX   PubMed=3518877;
RX   PubMed=6744315;
RX   PubMed=6935474;
RX   PubMed=11921286;
RX   PubMed=15846775;
RX   PubMed=16885334;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=24018021;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=25997541;
RX   PubMed=26589293;
RX   PubMed=26621286;
RX   PubMed=27270441;
RX   PubMed=27397505;
RX   PubMed=29732388;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35839778;
WW   https://www.synapse.org/UC25
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   From: Scott and White Clinic; Temple; USA.
CC   Population: Caucasian.
CC   Doubling time: ~25-32 hours (DSMZ=ACC-426).
CC   HLA typing: A*02:01,24:02; B*07:02,44:02; C*05:01,07:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (Cosmic-CLP; DepMap).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.06%; Native American=0%; East Asian, North=1.26%; East Asian, South=0%; South Asian=1.43%; European, North=65.29%; European, South=31.96% (PubMed=30894373).
ST   Source(s): Cosmic-CLP; DSMZ; PubMed=27270441
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 12
ST   D16S539: 8,11
ST   D18S51: 15,17
ST   D19S433: 14,15
ST   D21S11: 28,30
ST   D2S1338: 19,20
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 8,11
ST   D8S1179: 9,12
ST   FGA: 25
ST   Penta D: 9,11
ST   Penta E: 7,14
ST   TH01: 7,8,9.3 (DSMZ)
ST   TH01: 7,9.3 (PubMed=27270441)
ST   TH01: 7,10 (Cosmic-CLP)
ST   TPOX: 9,11
ST   vWA: 16,17
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   84Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 38
//
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RX   PubMed=11921286; DOI=10.1002/gcc.10050;
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RT   loci in bladder cancer cell lines.";
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RT   "Telomerase reverse transcriptase promoter mutations in bladder
RT   cancer: high frequency across stages, detection in urine, and lack of
RT   association with outcome.";
RL   Eur. Urol. 65:360-366(2014).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst C.D., Platt F.M., Knowles M.A.;
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
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RA   Knowles M.A.;
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RT   urothelial cancer.";
RL   PLoS ONE 8:E84411-E84411(2013).
//
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RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
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RA   Loewer M., Sahin U., Castle J.C.;
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RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
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RT   genomic resource for functional studies.";
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//
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RT   biology and drug response.";
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//
RX   PubMed=29732388; DOI=10.3233/BLC-180167;
RA   Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.;
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
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RL   Cancer Cell 40:835-849.e8(2022).
//