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Cellosaurus SW626 (CVCL_1725)

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Cell line name SW626
Synonyms SW-626; SW 626
Accession CVCL_1725
Secondary accession CVCL_IW65
Resource Identification Initiative To cite this cell line use: SW626 (RRID:CVCL_1725)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; USA.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Although established from a surgical specimen from a cystadenocarcinoma of the ovary in a 46 year old female Caucasian, it now seems likely that it was established from an ovarian metastasis of a colonic carcinoma (PubMed=10433623).
Misspelling: SWS-26; In PubMed=20106510.
Sequence variations Homozygous for APC p.Arg976fs*9 (c.2926_2927insA) (ATCC; CCLE; Cosmic-CLP).
Heterozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (PubMed=12068308; PubMed=25846456; CCLE; Cosmic-CLP).
Homozygous for SMAD4 p.Asp351His (c.1051G>C) (PubMed=25846456; CCLE; Cosmic-CLP).
Homozygous for TP53 p.Gly262Val (c.785G>T) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.06
Native American0.08
East Asian, North0.77
East Asian, South0
South Asian2.55
European, North65.38
European, South31.17
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Ovary.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133825
D3S135815,17
D5S81812
D7S82010,12 (ATCC; Cosmic-CLP)
12 (PubMed=25877200)
D8S117911
D13S31711 (ATCC; PubMed=25877200)
11,12 (Cosmic-CLP)
D16S53911
D18S5114
D19S43314
D21S1127,29
FGA21,23
Penta D9,13
Penta E7,11
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
http://www.cellresource.cn/fdetail.aspx?id=886
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6220172
Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=9698466; DOI=10.1006/gyno.1998.5039
Maxwell G.L., Risinger J.I., Tong B., Shaw H., Barrett J.C., Berchuck A., Futreal P.A.
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
Gynecol. Oncol. 70:13-16(1998)

PubMed=10433623; DOI=10.1093/jnci/91.15.1327
Furlong M.T., Hough C.D., Sherman-Baust C.A., Pizer E.S., Morin P.J.
Evidence for the colonic origin of ovarian cancer cell line SW626.
J. Natl. Cancer Inst. 91:1327-1328(1999)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20106510; DOI=10.1016/j.ygyno.2009.12.002
Byron S.A., Gartside M.G., Wellens C.L., Goodfellow P.J., Birrer M.J., Campbell I.G., Pollock P.M.
FGFR2 mutations are rare across histologic subtypes of ovarian cancer.
Gynecol. Oncol. 117:125-129(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007
Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S., Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G., Cremona M., Carey M.S., Li J., Li Y., Aslan O., O'Leary J.J., Mills G.B., Hennessy B.T.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=25846456; DOI=10.3892/ijo.2015.2951
Takenaka M., Saito M., Iwakawa R., Yanaihara N., Saito M., Kato M., Ichikawa H., Shibata T., Yokota J., Okamoto A., Kohno T.
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Int. J. Oncol. 46:2389-2398(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; HTB-78
CCTCC; GDC0112
ECACC; 91091203
KCB; KCB 2013039YJ
Cell line databases/resources CLDB; cl4446
CCLE; SW626_OVARY
CCRID; 3142C0001000000118
Cell_Model_Passport; SIDM01168
Cosmic-CLP; 909753
DepMap; ACH-001399
LINCS_LDP; LCL-1529
Ontologies BTO; BTO:0001881
CLO; CLO_0009197
CLO; CLO_0009222
Biological sample resources BioSample; SAMN03472756
BioSample; SAMN03472876
Chemistry resources ChEMBL-Cells; CHEMBL3308130
ChEMBL-Targets; CHEMBL1075593
GDSC; 909753
PharmacoDB; SW626_1542_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM186459
GEO; GSM186460
GEO; GSM313714
GEO; GSM659406
GEO; GSM784571
GEO; GSM1670509
Other Wikidata; Q54971190
Polymorphism and mutation databases Cosmic; 724882
Cosmic; 844346
Cosmic; 849608
Cosmic; 867865
Cosmic; 897437
Cosmic; 909753
Cosmic; 920358
Cosmic; 948285
Cosmic; 949229
Cosmic; 1044244
Cosmic; 1113284
Cosmic; 1312194
Cosmic; 1707572
Cosmic; 2582804
Cosmic; 2674699
IARC_TP53; 27252
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number28