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Cellosaurus SW626 (CVCL_1725)

Cell line name SW626
Synonyms SW-626; SW 626
Accession CVCL_1725
Resource Identification Initiative To cite this cell line use: SW626 (RRID:CVCL_1725)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; Texas; USA.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Caution: Although established from a surgical specimen from a cystadenocarcinoma of the ovary in a 46 year old female Caucasian, it now seems likely that it was established from an ovarian metastasis of a colonic carcinoma (PubMed=10433623).
Sequence variations Homozygous for APC p.Arg976fs*9 (c.2926_2927insA) (ATCC).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Ovary.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=25877200

D13S31711 (ATCC; PubMed=25877200)
11,12 (Cosmic-CLP)
D7S82010,12 (ATCC; Cosmic-CLP)
12 (PubMed=25877200)
Penta D9,13
Penta E7,11
Web pages http://tcpaportal.org/mclp/

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

Dracopoli N.C., Fogh J.
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=9698466; DOI=10.1006/gyno.1998.5039
Maxwell G.L., Risinger J.I., Tong B., Shaw H., Barrett J.C., Berchuck A., Futreal P.A.
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
Gynecol. Oncol. 70:13-16(1998)

PubMed=10433623; DOI=10.1093/jnci/91.15.1327
Furlong M.T., Hough C.D., Sherman-Baust C.A., Pizer E.S., Morin P.J.
Evidence for the colonic origin of ovarian cancer cell line SW626.
J. Natl. Cancer Inst. 91:1327-1328(1999)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007
Stordal B., Timms K., Farrelly A., Gallagher D., Busschots S., Renaud M., Thery J., Williams D., Potter J., Tran T., Korpanty G., Cremona M., Carey M., Li J., Li Y., Aslan O., O'Leary J.J., Mills G.B., Hennessy B.T.
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cell line collections ATCC; HTB-78
ECACC; 91091203
KCB; KCB 2013039YJ
Cell line databases/resources CLDB; cl4446
Cosmic-CLP; 909753
GDSC; 909753
Ontologies BTO; BTO:0001881
CLO; CLO_0009197
CLO; CLO_0009222
Biological sample resources BioSample; SAMN03472756
BioSample; SAMN03472876
Chemistry resources ChEMBL-Cells; CHEMBL3308130
ChEMBL-Targets; CHEMBL1075593
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM186459
GEO; GSM186460
GEO; GSM313714
GEO; GSM659406
GEO; GSM784571
GEO; GSM1670509
Other Wikidata; Q54971190
Polymorphism and mutation databases Cosmic; 724882
Cosmic; 844346
Cosmic; 849608
Cosmic; 867865
Cosmic; 897437
Cosmic; 909753
Cosmic; 920358
Cosmic; 948285
Cosmic; 949229
Cosmic; 1044244
Cosmic; 1113284
Cosmic; 1707572
Cosmic; 2582804
Cosmic; 2674699