Home  |  Contact

Cellosaurus SW756 (CVCL_1727)

[Text version]

Cell line name SW756
Synonyms SW-756; SW 756
Accession CVCL_1727
Resource Identification Initiative To cite this cell line use: SW756 (RRID:CVCL_1727)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
From: Scott and White Clinic; Temple; USA.
Characteristics: Contains a complete HPV18 genome.
Doubling time: 1.6 days (PubMed=29156801).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations KRAS p.Gly12Cys (c.34G>T) (PubMed=12068308).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.44
Native American0
East Asian, North3.59
East Asian, South0
South Asian0.36
European, North58.26
European, South34.34
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; PubMed=29156801

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010,12
D13S31711
D16S53912,13
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=924690; DOI=10.1002/ijc.2910200505
Kerbel R.S., Pross H.F., Leibovitz A.
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Int. J. Cancer 20:673-679(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7129487; DOI=10.1007/BF02796428
Freedman R.S., Bowen J.M., Leibovitz A., Pathak S., Siciliano M.J., Gallager H.S., Giovanella B.C.
Characterization of a cell line (SW756) derived from a human squamous carcinoma of the uterine cervix.
In Vitro 18:719-726(1982)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3029760; DOI=10.1073/pnas.84.4.1070
Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24134916; DOI=10.1186/1755-8166-6-44
McCormack A., Fan J.L., Duesberg M., Bloomfield M., Fiala C., Duesberg P.
Individual karyotypes at the origins of cervical carcinomas.
Mol. Cytogenet. 6:44-44(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-10302
Cell line databases/resources CCLE; SW756_CERVIX
Cell_Model_Passport; SIDM01174
Cosmic-CLP; 724839
DepMap; ACH-001402
GDSC; 724839
IGRhCellID; SW756
IGRhCellID; SW756GEO
LINCS_LDP; LCL-1544
Ontologies CLO; CLO_0009223
EFO; EFO_0002370
Biological sample resources BioSample; SAMN03471299
Chemistry resources ChEMBL-Cells; CHEMBL3308790
ChEMBL-Targets; CHEMBL1075594
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM113867
GEO; GSM253303
GEO; GSM675739
GEO; GSM685443
GEO; GSM1670511
Other Wikidata; Q54971203
Polymorphism and mutation databases Cosmic; 724839
Cosmic; 925359
Cosmic; 1131522
Cosmic; 1193032
Cosmic; 2660194
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number23