ID   SW756
AC   CVCL_1727
SY   SW-756; SW 756
DR   CLO; CLO_0009223
DR   EFO; EFO_0002370
DR   ATCC; CRL-10302
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471299
DR   cancercelllines; CVCL_1727
DR   Cell_Model_Passport; SIDM01174
DR   ChEMBL-Cells; CHEMBL3308790
DR   ChEMBL-Targets; CHEMBL1075594
DR   Cosmic; 724839
DR   Cosmic; 925359
DR   Cosmic; 1131522
DR   Cosmic; 1193032
DR   Cosmic; 2660194
DR   Cosmic-CLP; 724839
DR   DepMap; ACH-001402
DR   EGA; EGAS00001000978
DR   GDSC; 724839
DR   GEO; GSM113867
DR   GEO; GSM253303
DR   GEO; GSM675739
DR   GEO; GSM685443
DR   GEO; GSM1670511
DR   IARC_TP53; 27583
DR   IGRhCellID; SW756
DR   IGRhCellID; SW756GEO
DR   LINCS_LDP; LCL-1544
DR   PharmacoDB; SW756_1544_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1727
DR   PubChem_Cell_line; CVCL_1727
DR   Wikidata; Q54971203
RX   PubMed=833871;
RX   PubMed=924690;
RX   PubMed=3029760;
RX   PubMed=3518877;
RX   PubMed=6935474;
RX   PubMed=7129487;
RX   PubMed=12068308;
RX   PubMed=15531914;
RX   PubMed=20215515;
RX   PubMed=24134916;
RX   PubMed=27397505;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=35692560;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   From: Scott and White Clinic; Temple; USA.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10302.
CC   Population: Caucasian.
CC   Virology: Contains a complete HPV18 genome.
CC   Doubling time: 1.6 days (PubMed=29156801).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (PubMed=12068308; Cosmic-CLP; DepMap).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=3.44%; Native American=0%; East Asian, North=3.59%; East Asian, South=0%; South Asian=0.36%; European, North=58.26%; European, South=34.34% (PubMed=30894373).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; Cosmic-CLP; DepMap; PubMed=29156801
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 14,17
ST   D21S11: 30
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 11,13
ST   FGA: 20,22
ST   Penta D: 9,12
ST   Penta E: 11,12
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 37
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=924690; DOI=10.1002/ijc.2910200505;
RA   Kerbel R.S., Pross H.F., Leibovitz A.;
RT   "Analysis of established human carcinoma cell lines for
RT   lymphoreticular-associated membrane receptors.";
RL   Int. J. Cancer 20:673-679(1977).
//
RX   PubMed=3029760; DOI=10.1073/pnas.84.4.1070;
RA   Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.;
RT   "Papillomavirus sequences integrate near cellular oncogenes in some
RT   cervical carcinomas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7129487; DOI=10.1007/BF02796428;
RA   Freedman R.S., Bowen J.M., Leibovitz A., Pathak S., Siciliano M.J.,
RA   Gallager H.S., Giovanella B.C.;
RT   "Characterization of a cell line (SW756) derived from a human squamous
RT   carcinoma of the uterine cervix.";
RL   In Vitro 18:719-726(1982).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44;
RA   McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.H.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628;
RA   de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J.,
RA   Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.;
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//