ID   TC-YIK
AC   CVCL_1737
SY   TCYIK
DR   CLO; CLO_0050913
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472316
DR   Cell_Model_Passport; SIDM00234
DR   ChEMBL-Cells; CHEMBL3308250
DR   ChEMBL-Targets; CHEMBL2366324
DR   Cosmic; 946357
DR   Cosmic; 1995659
DR   Cosmic-CLP; 946357
DR   DepMap; ACH-002201
DR   EGA; EGAS00001000978
DR   GDSC; 946357
DR   GEO; GSM1670527
DR   IARC_TP53; 27258
DR   PharmacoDB; TCYIK_1568_2019
DR   PubChem_Cell_line; CVCL_1737
DR   RCB; RCB0443
DR   Wikidata; Q54971829
RX   PubMed=1849445;
RX   PubMed=10391092;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Characteristics: Established from the YIK-1 xenograft which was obtained by mutliple serial transplantation of the original tumor in nude mice.
CC   Doubling time: ~21.6 hours (Note=At 119th passage) (PubMed=1849445).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 9885; ARID4A; Simple; p.Glu565Ter (c.1693G>T); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=74.47%; East Asian, South=25.52%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
ST   Source(s): Cosmic-CLP; RCB
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,9
ST   D16S539: 9,11
ST   D5S818: 10,11
ST   D7S820: 8,11
ST   TH01: 7,9
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C7982; Cervical small cell neuroendocrine carcinoma
DI   ORDO; Orphanet_213777; High-grade neuroendocrine carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   31Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 29
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RX   PubMed=1849445; DOI=10.1002/1097-0142(19910501)67:9<2327::AID-CNCR2820670919>3.0.CO;2-F;
RA   Ichimura H., Yamasaki M., Tamura I., Katsumoto T., Sawada M.,
RA   Kurimura O., Furuyama J.-i., Kurimura T.;
RT   "Establishment and characterization of a new cell line TC-YIK
RT   originating from argyrophil small cell carcinoma of the uterine cervix
RT   integrating HPV16 DNA.";
RL   Cancer 67:2327-2332(1991).
//
RX   PubMed=10391092; DOI=10.1111/j.1349-7006.1999.tb00779.x;
RA   Ichimura H., Sakashita N., Iida T., Chisaka T., Yasuda H., Kita M.,
RA   Yuasa S., Imanishi J.;
RT   "Differentiation of a cell line of human cervical argyrophil small
RT   cell carcinoma to macrophage lineage cells.";
RL   Jpn. J. Cancer Res. 90:523-529(1999).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//