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Cellosaurus TGBC1TKB (CVCL_1769)

[Text version]

Cell line name TGBC1TKB
Accession CVCL_1769
Resource Identification Initiative To cite this cell line use: TGBC1TKB (RRID:CVCL_1769)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 41 hours (PubMed=9824643); 45 hours (PubMed=32293552).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Cys176fs*6 (c.525_526insGCGC); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.16
East Asian, North75.35
East Asian, South24.48
South Asian0
European, North0
European, South0
Disease Gallbladder undifferentiated carcinoma (NCIt: C9167)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3339 ! TGBC2TKB
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; RCB

D13S3178 (DepMap)
8,11 (Cosmic-CLP; RCB)
Penta D13
Penta E15

Run an STR similarity search on this cell line

PubMed=21533411; DOI=10.3892/ijo.10.3.545
Moon Y., Dahlberg W., Yu Y., Ohno T., Todoroki T., Little J.
Radiosensitivity of human biliary tract cancer cell lines in vitro.
Int. J. Oncol. 10:545-551(1997)

PubMed=9824643; DOI=10.3892/ijo.13.6.1269
Koike N., Todoroki T., Kawamoto T., Yoshida S., Kashiwagi H., Fukao K., Ohno T., Watanabe T.
The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.
Int. J. Oncol. 13:1269-1274(1998)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21451941; DOI=10.1007/s00534-011-0376-7
Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y., Tsuchiya T., Gotoh M.
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J. Hepatobiliary Pancreat. Sci. 18:700-711(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=32293552; DOI=10.1186/s40659-020-00282-7
Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H., Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J., Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C., Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Biol. Res. 53:13.1-13.17(2020)

PubMed=32899426; DOI=10.3390/cancers12092510
Scherer D., Davila Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Bermejo J.L.
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

Cell line collections RCB; RCB1129
Cell line databases/resources CCLE; TGBC1TKB_BILIARY_TRACT
Cell_Model_Passport; SIDM00252
Cosmic-CLP; 909769
DepMap; ACH-001861
Ontologies CLO; CLO_0050019
Biological sample resources BioSample; SAMN03472156
Chemistry resources ChEMBL-Cells; CHEMBL3308852
ChEMBL-Targets; CHEMBL2366089
GDSC; 909769
PharmacoDB; TGBC1TKB_1590_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670540
Other Wikidata; Q54972238
Polymorphism and mutation databases Cosmic; 909769
IARC_TP53; 27261
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number32