ID   TGBC1TKB
AC   CVCL_1769
SY   TGBC-1-TKB; TGBC-1TKB; TGBC1-TKB; TGBC-1; TGBC1
DR   CLO; CLO_0050019
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472156
DR   Cell_Model_Passport; SIDM00252
DR   ChEMBL-Cells; CHEMBL3308852
DR   ChEMBL-Targets; CHEMBL2366089
DR   Cosmic; 909769
DR   Cosmic-CLP; 909769
DR   DepMap; ACH-001861
DR   EGA; EGAS00001000978
DR   GDSC; 909769
DR   GEO; GSM1670540
DR   IARC_TP53; 27261
DR   LINCS_LDP; LCL-1343
DR   PharmacoDB; TGBC1TKB_1590_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1769
DR   RCB; RCB1129
DR   Wikidata; Q54972238
RX   PubMed=9824643;
RX   PubMed=20164919;
RX   PubMed=21451941;
RX   PubMed=21533411;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=32293552;
RX   PubMed=32899426;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 41 hours (PubMed=9824643); 45 hours (PubMed=32293552).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys176fs*6 (c.525_526insGCGC); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.16%; East Asian, North=75.35%; East Asian, South=24.48%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): Cosmic-CLP; DepMap; RCB
ST   Amelogenin: X
ST   CSF1PO: 14
ST   D13S317: 8 (DepMap)
ST   D13S317: 8,11 (Cosmic-CLP; RCB)
ST   D16S539: 9,11
ST   D18S51: 14,18
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 9,13
ST   D8S1179: 14,16
ST   FGA: 25
ST   Penta D: 13
ST   Penta E: 15
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C9167; Gallbladder undifferentiated carcinoma
DI   ORDO; Orphanet_56044; Carcinoma of gallbladder and extrahepatic biliary tract
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_3339 ! TGBC2TKB
SX   Female
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 37
//
RX   PubMed=9824643; DOI=10.3892/ijo.13.6.1269;
RA   Koike N., Todoroki T., Kawamoto T., Yoshida S., Kashiwagi H.,
RA   Fukao K., Ohno T., Watanabe T.;
RT   "The invasion potentials of human biliary tract carcinoma cell lines:
RT   correlation between invasiveness and morphologic characteristics.";
RL   Int. J. Oncol. 13:1269-1274(1998).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=21451941; DOI=10.1007/s00534-011-0376-7;
RA   Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y.,
RA   Tsuchiya T., Gotoh M.;
RT   "Gene expression analysis for predicting gemcitabine resistance in
RT   human cholangiocarcinoma.";
RL   J. Hepatobiliary Pancreat. Sci. 18:700-711(2011).
//
RX   PubMed=21533411; DOI=10.3892/ijo.10.3.545;
RA   Moon Y., Dahlberg W.K., Yu Y.-J., Ohno T., Todoroki T., Little J.B.;
RT   "Radiosensitivity of human biliary tract cancer cell lines in vitro.";
RL   Int. J. Oncol. 10:545-551(1997).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=32293552; DOI=10.1186/s40659-020-00282-7;
RA   Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H.,
RA   Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J.,
RA   Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C.,
RA   Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.;
RT   "Functional and genomic characterization of three novel cell lines
RT   derived from a metastatic gallbladder cancer tumor.";
RL   Biol. Res. 53:13.1-13.17(2020).
//
RX   PubMed=32899426; DOI=10.3390/cancers12092510;
RA   Scherer D., Davila Lopez M., Goeppert B., Abrahamsson S.,
RA   Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D.,
RA   Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.;
RT   "RNA sequencing of hepatobiliary cancer cell lines: data and
RT   applications to mutational and transcriptomic profiling.";
RL   Cancers (Basel) 12:2510.1-2510.14(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//