Cellosaurus TT (CVCL_1774)

Cell line name TT
Synonyms MTC-TT
Accession CVCL_1774
Resource Identification Initiative To cite this cell line use: TT (RRID:CVCL_1774)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Heterozygous for RET p.Cys634Trp.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Hereditary thyroid gland medullary carcinoma (NCIt: C46099)
Multiple endocrine neoplasia type 2 (NCIt: C123329)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC; ICLC

Markers:
AmelogeninX
CSF1PO10,13
D13S31711
D16S53912,13
D21S1129,32.2
D5S81812,13
D7S82010,12
TH016,9
TPOX8,11
vWA16,18
Publications

CLPUB00116
Leong S.S., Horoszewicz J.S., Shimaoka K., Friedmann M., Kawinski E., Song M.J., Chu T., Baylin S.B., Mirand E.A.
A new cell line for study of human medullary thyroid carcinoma.
(In) Advances in thyroid neoplasia; Andreoli M., Monaco H., Robbins J. (eds.); pp.95-108; Field Educational Italia; Roma (1981)

PubMed=3467830; DOI=10.1016/0165-4608(87)90156-7
Tanaka K., Baylin S.B., Nelkin B.D., Testa J.R.
Cytogenetic studies of a human medullary thyroid carcinoma cell line.
Cancer Genet. Cytogenet. 25:27-35(1987)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E
Cooley L.D., Elder F.F.B., Knuth A., Gagel R.F.
Cytogenetic characterization of three human and three rat medullary thyroid carcinoma cell lines.
Cancer Genet. Cytogenet. 80:138-149(1995)

PubMed=7864888; DOI=10.1006/bbrc.1995.1287
Carlomagno F., Salvatore D., Santoro M., de Franciscis V., Quadro L., Panariello L., Colantuoni V., Fusco A.
Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line.
Biochem. Biophys. Res. Commun. 207:1022-1028(1995)

PubMed=9046062
Zabel M., Grzeszkowiak J.
Characterisation of thyroid medullary carcinoma TT cell line.
Histol. Histopathol. 12:283-289(1997)

PubMed=19897677; DOI=10.1210/jc.2009-1485
Zhu W., Hai T., Ye L., Cote G.J.
Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on Ret proto-oncogene activity.
J. Clin. Endocrinol. Metab. 95:439-444(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-1803
BCRC; 60346
BCRJ; 0259
ECACC; 92050721
ICLC; HTL98004
KCB; KCB 201301YJ
Cell line databases/resources CLDB; cl4547
CLDB; cl4901
CCLE; TT_THYROID
CCRID; 3111C0001CCC000268
CCRID; 3131C0001000700078
CCRID; 3142C0001000000072
Cosmic-CLP; 930299
GDSC; 930299
IGRhCellID; TT
LINCS_LDP; LCL-1690
Lonza; 1097
Ontologies BTO; BTO:0003074
CLO; CLO_0009421
EFO; EFO_0002382
Biological sample resources BioSample; SAMN03471250
Chemistry resources ChEMBL-Cells; CHEMBL3308145
ChEMBL-Targets; CHEMBL2366083
Gene expression databases GEO; GSM887714
GEO; GSM888807
GEO; GSM1374966
GEO; GSM1670548
Polymorphism and mutation databases Cosmic; 796049
Cosmic; 796731
Cosmic; 930299
Cosmic; 1005455
Cosmic; 1094763
Cosmic; 1175889
Cosmic; 1239955
Cosmic; 1608835
Cosmic; 1612901
Cosmic; 1699419
Cosmic; 1876248
Cosmic; 2036697
Cosmic; 2050374