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Cellosaurus TT (CVCL_1774)

[Text version]
Cell line name TT
Synonyms MTC-TT
Accession CVCL_1774
Resource Identification Initiative To cite this cell line use: TT (RRID:CVCL_1774)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 83 hours (ATCC=CRL-1803).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Cell type: Parafollicular cell; CL=CL_0000570.
Sequence variations
  • Mutation; HGNC; 9967; RET; Simple; p.Cys634Trp (c.1902C>G); ClinVar=VCV000013918; Zygosity=Heterozygous (PubMed=7736432; PubMed=30737244; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11602; TBX3; Simple; p.Trp197Ter (c.591G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,03:01
HLA-BB*51:01,67:02
HLA-CC*12:03,14:02
Class II
HLA-DQDQB1*05:01,06:07
HLA-DRDRB1*01:01,11:10
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.11
Native American0
East Asian, North2.03
East Asian, South0
South Asian6.11
European, North32.67
European, South57.09
Disease Hereditary thyroid gland medullary carcinoma (NCIt: C46099)
Multiple endocrine neoplasia type 2 (NCIt: C123329)
Familial medullary thyroid carcinoma (ORDO: Orphanet_99361)
Multiple endocrine neoplasia type 2 (ORDO: Orphanet_653)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; Cosmic-CLP; ECACC; ICLC; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,23
D3S135815
D5S81812,13
D7S82010,12
D8S117915,16
D13S31711
D16S53912,13
D18S5112
D19S43314,15
D21S1129,32.2
FGA21,25
TH016,9
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/normal-growth-and-morphology-of-atcc-crl-1803-the-tt-cells
Publications

CLPUB00116
Leong S.S., Horoszewicz J.S., Shimaoka K., Friedmann M., Kawinski E., Song M.J., Chu T., Baylin S.B., Mirand E.A.
A new cell line for study of human medullary thyroid carcinoma.
(In) Advances in thyroid neoplasia; Andreoli M., Monaco H., Robbins J. (eds.); pp.95-108; Field Educational Italia; Roma (1981)

PubMed=3467830; DOI=10.1016/0165-4608(87)90156-7
Tanaka K., Baylin S.B., Nelkin B.D., Testa J.R.
Cytogenetic studies of a human medullary thyroid carcinoma cell line.
Cancer Genet. Cytogenet. 25:27-35(1987)

PubMed=2519210
Kameya T., Kadoya K., Iguchi H.
Characterization and calcitonin secretion of a human well differentiated C-cell tumor cell line.
Hum. Cell 2:231-237(1989)

PubMed=1516062
Yoshimoto K., Iwahana H., Fukuda A., Sano T., Saito S., Itakura M.
Role of p53 mutations in endocrine tumorigenesis: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Cancer Res. 52:5061-5064(1992)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E
Cooley L.D., Elder F.F.B., Knuth A., Gagel R.F.
Cytogenetic characterization of three human and three rat medullary thyroid carcinoma cell lines.
Cancer Genet. Cytogenet. 80:138-149(1995)

PubMed=7864888; DOI=10.1006/bbrc.1995.1287
Carlomagno F., Salvatore D., Santoro M., de Franciscis V., Quadro L., Panariello L., Colantuoni V., Fusco A.
Point mutation of the RET proto-oncogene in the TT human medullary thyroid carcinoma cell line.
Biochem. Biophys. Res. Commun. 207:1022-1028(1995)

PubMed=9046062; DOI=10.14670/HH-12.283
Zabel M., Grzeszkowiak J.
Characterisation of thyroid medullary carcinoma TT cell line.
Histol. Histopathol. 12:283-289(1997)

PubMed=11751535; DOI=10.1093/clinchem/48.1.25
Zammatteo N., Lockman L., Brasseur F., De Plaen E., Lurquin C., Lobert P.-E., Hamels S., Boon T., Remacle J.
DNA microarray to monitor the expression of MAGE-A genes.
Clin. Chem. 48:25-34(2002)

PubMed=19897677; DOI=10.1210/jc.2009-1485
Zhu W., Hai T., Ye L., Cote G.J.
Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on Ret proto-oncogene activity.
J. Clin. Endocrinol. Metab. 95:439-444(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22538498; DOI=10.1159/000338793
Grozinsky-Glasberg S., Shimon I., Rubinfeld H.
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-1803
BCRC; 60346
BCRJ; 0259
CCTCC; GDC0073
CLS; 305027
ECACC; 92050721
ICLC; HTL98004
KCB; KCB 2013001YJ
Cell line databases/resources CLO; CLO_0009421
CLDB; cl4547
CLDB; cl4901
cancercelllines; CVCL_1774
CCRID; 1101HUM-PUMC000268
CCRID; 3101HUMTCHu78
CCRID; 4201HUM-CCTCC00073
Cell_Model_Passport; SIDM00484
Cosmic-CLP; 930299
DepMap; ACH-001321
IGRhCellID; TT
LINCS_LDP; LCL-1690
Lonza; 1097
Anatomy/cell type resources BTO; BTO:0003074
Biological sample resources BioSample; SAMN03471250
BioSample; SAMN10988442
Chemistry resources ChEMBL-Cells; CHEMBL3308145
ChEMBL-Targets; CHEMBL2366083
GDSC; 930299
PharmacoDB; TT_1606_2019
PubChem_Cell_line; CVCL_1774
Encyclopedic resources Wikidata; Q54973178
Experimental variables resources EFO; EFO_0002382
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887714
GEO; GSM888807
GEO; GSM1374966
GEO; GSM1670548
Polymorphism and mutation databases Cosmic; 796049
Cosmic; 796731
Cosmic; 930299
Cosmic; 1005455
Cosmic; 1094763
Cosmic; 1175889
Cosmic; 1239955
Cosmic; 1608835
Cosmic; 1612901
Cosmic; 1699419
Cosmic; 1876248
Cosmic; 2036697
Cosmic; 2050374
IARC_TP53; 27017
IARC_TP53; 30182
LiGeA; CCLE_452
Progenetix; CVCL_1774
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number38