Home  |  Contact

Cellosaurus TUR (CVCL_1775)

[Text version]

Cell line name TUR
Synonyms TPA-U937-resistant
Accession CVCL_1775
Resource Identification Initiative To cite this cell line use: TUR (RRID:CVCL_1775)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.04
East Asian, North0.5
East Asian, South0
South Asian1.33
European, North75.18
European, South22.94
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S8209,11
D13S31710,12
D16S53912
TH016,9.3
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Web pages http://www.infarktforschung.de/macrophages_cell_lines.html
Publications

PubMed=8398907
Hass R., Hirano M., Kharbanda S., Rubin E., Meinhardt G., Kufe D.
Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase.
Cell Growth Differ. 4:657-663(1993)

PubMed=7720732
Hass R., Meinhardt G., Hadam M., Bartels H.
Characterization of human TUR leukemia cells: continued cell cycle progression in the presence of phorbol ester is associated with resistance to apoptosis.
Eur. J. Cell Biol. 65:408-416(1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections ATCC; CRL-2367
Cell line databases/resources CCLE; TUR_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01205
Cosmic-CLP; 909773
DepMap; ACH-002314
LINCS_LDP; LCL-2063
Ontologies CLO; CLO_0009447
Biological sample resources BioSample; SAMN03471833
Chemistry resources ChEMBL-Cells; CHEMBL3308519
ChEMBL-Targets; CHEMBL2366218
GDSC; 909773
PharmacoDB; TUR_1613_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM186464
GEO; GSM1670551
Other Wikidata; Q54973376
Polymorphism and mutation databases Cosmic; 683549
Cosmic; 909773
IARC_TP53; 27263
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number26