ID   VMRC-MELG
AC   CVCL_1789
SY   VMRCMELG; Leggee; Virginia Mason Research Center-Melanoma G
DR   CLO; CLO_0037136
DR   ArrayExpress; E-MTAB-783
DR   BioSample; SAMN03471062
DR   cancercelllines; CVCL_1789
DR   Cell_Model_Passport; SIDM00319
DR   ChEMBL-Cells; CHEMBL3308809
DR   ChEMBL-Targets; CHEMBL1075609
DR   Cosmic; 930301
DR   Cosmic-CLP; 930301
DR   DepMap; ACH-001704
DR   GDSC; 930301
DR   IARC_TP53; 27587
DR   JCRB; JCRB0074
DR   LINCS_LDP; LCL-1258
DR   PharmacoDB; VMRCMELG_1657_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1789
DR   Wikidata; Q54993286
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   From: Bean M.A.; Virginia Mason Research Center; Seattle; USA.
CC   Population: Caucasian.
CC   Doubling time: 60-80 hours (Note=Lot 06232008) (JCRB=JCRB0074).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.151-1G>A; ClinVar=VCV000635365; Zygosity=Homozygous; Note=Splice acceptor mutation (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=4.63%; Native American=0%; East Asian, North=0.15%; East Asian, South=2.24%; South Asian=0.66%; European, North=63.56%; European, South=28.76% (PubMed=30894373).
ST   Source(s): Cosmic-CLP; DepMap; JCRB
ST   Amelogenin: X (Cosmic-CLP; DepMap)
ST   Amelogenin: X,Y (JCRB)
ST   CSF1PO: 10
ST   D13S317: 8,11
ST   D16S539: 12
ST   D18S51: 15,18
ST   D21S11: 27,32.2
ST   D3S1358: 14,16
ST   D5S818: 10,13
ST   D7S820: 8,10
ST   D8S1179: 14
ST   FGA: 19,23
ST   Penta D: 10,12
ST   Penta E: 5
ST   TH01: 6,7
ST   TPOX: 9,11
ST   vWA: 17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 30
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//