Home  |  Contact

Cellosaurus 42-MG-BA (CVCL_1798)

[Text version]

Cell line name 42-MG-BA
Synonyms 42MGBA
Accession CVCL_1798
Resource Identification Initiative To cite this cell line use: 42-MG-BA (RRID:CVCL_1798)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 48-54 hours (PubMed=9604998); ~40 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger; PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations PTEN c.164+1_164+2insG; aberrant splicing and complete loss of expression (PubMed=28464039).
TP53 p.Thr211Ile (c.632C>T) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.01
Native American0
East Asian, North4.88
East Asian, South0
South Asian0
European, North63.22
European, South31.9
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S82010
D13S31713
D16S53910
TH016,8
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=9604998
Perzelova A., Macikova I., Mraz P., Bizik I., Steno J.
Characterization of two new permanent glioma cell lines 8-MG-BA and 42-MG-BA.
Neoplasma 45:25-29(1998)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28464039; DOI=10.1371/journal.pone.0176683
Hill V.K., Kim J.-S., James C.D., Waldman T.
Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing.
PLoS ONE 12:E0176683-E0176683(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-431
Cell line databases/resources CCLE; 42MGBA_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00982
Cosmic-CLP; 687561
DepMap; ACH-000323
GDSC; 687561
LINCS_LDP; LCL-1347
Ontologies CLO; CLO_0001367
Biological sample resources BioSample; SAMN03473596
BioSample; SAMN10988275
Chemistry resources PharmacoDB; 42MGBA_16_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM326214
GEO; GSM886839
GEO; GSM887902
GEO; GSM1669567
Other Wikidata; Q54603004
Polymorphism and mutation databases Cosmic; 687561
Cosmic; 1746946
Cosmic; 1995325
Cosmic; 2060804
Cosmic; 2302328
IARC_TP53; 28274
LiGeA; CCLE_146
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24