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Cellosaurus Karpas-1106P (CVCL_1821)

[Text version]

Cell line name Karpas-1106P
Synonyms Karpas-1106p; KARPAS-1106P; Karpas 1106P; KARPAS 1106P; KARPAS1106P; Karpas1106P; Karpas-1106; Karpas 1106; Karpas1106; K1106
Accession CVCL_1821
Resource Identification Initiative To cite this cell line use: Karpas-1106P (RRID:CVCL_1821)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~60-100 hours (ECACC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.68
Native American0.48
East Asian, North0.25
East Asian, South1.18
South Asian11.86
European, North19.43
European, South65.12
Disease Primary mediastinal (thymic) large B-cell lymphoma (NCIt: C9280)
Primary mediastinal large B-cell lymphoma (ORDO: Orphanet_98838)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_QY35 ! Karpas-1106A
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S8188,14
D7S8209,13
D8S11798,15
D13S3179,11
D16S5399
D18S5121
D21S1129,30
FGA21,22
Penta D8,11
Penta E7
TH016
TPOX9,11
vWA18,20

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=7949096; DOI=10.1182/blood.V84.10.3422.3422
Nacheva E., Dyer M.J.S., Metivier C., Jadayel D., Stranks G., Morilla R., Heward J.M., Holloway T., O'Connor S., Bevan P.C., Larsen C.-J., Karpas A.
B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression.
Blood 84:3422-3428(1994)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D., Yuille M.A., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=9724100; DOI=10.1002/(SICI)1097-0215(19980925)78:1<100::AID-IJC16>3.0.CO;2-F
Tamura A., Akagi T., Nakazawa N., Kashima K., Nakamura S., Karpas A., Silverman G.A., Morishima Y., Taniwaki M., Seto M.
Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones.
Int. J. Cancer 78:100-105(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-545 - Discontinued
ECACC; 06072607
Cell line databases/resources CCLE; KARPAS1106P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01011
Cosmic-CLP; 1327773
DepMap; ACH-002254
Lonza; 1123
Ontologies EFO; EFO_0006606
Biological sample resources BioSample; SAMN03470811
Chemistry resources GDSC; 1327773
PharmacoDB; KARPAS1106P_727_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM119503
GEO; GSM157143
GEO; GSM380128
GEO; GSM552445
GEO; GSM1374584
GEO; GSM1374585
GEO; GSM1669973
Other Wikidata; Q54899481
Polymorphism and mutation databases Cosmic; 1013890
Cosmic; 1278829
Cosmic; 1289975
Cosmic; 2276324
Cosmic; 2297035
Cosmic; 2437271
Cosmic; 2479248
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number24