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Cellosaurus Karpas-231 (CVCL_1822)

[Text version]

Cell line name Karpas-231
Synonyms KARPAS-231; Karpas 231; KARPAS 231; KARPAS231; K231
Accession CVCL_1822
Resource Identification Initiative To cite this cell line use: Karpas-231 (RRID:CVCL_1822)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~30-40 hours (DSMZ); ~60 hours (ECACC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia (ALL-L3).
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 1001; BCL6 + HGNC; 9211; POU2AF1; Name(s)=POU2AF1-BCL6, BOB1-LAZ3 (PubMed=8574789; PubMed=8618432).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North1.09
East Asian, South0
South Asian0.51
European, North68.07
European, South30.33
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ


Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/

PubMed=8324225; DOI=10.1182/blood.V82.1.231.bloodjournal821231
Nacheva E., Dyer M.J.S., Fischer P., Stranks G., Heward J.M., Marcus R.E., Grace C., Karpas A.
C-MYC translocations in de novo B-cell lineage acute leukemias with t(14;18) (cell lines Karpas 231 and 353).
Blood 82:231-240(1993)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

Galiegue-Zouitina S., Quief S., Hildebrand M.-P., Denis C., Lecocq G., Collyn-d'Hooghe M., Bastard C., Yuille M.A.R., Dyer M.J.S., Kerckaert J.-P.
Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3;11) (q27;q23) chromosomal translocation.
C. R. Acad. Sci. III, Sci. Vie 318:1125-1131(1995)

Galiegue Zouitina S., Quief S., Hildebrand M.-P., Denis C., Lecocq G., Collyn-d'Hooghe M., Bastard C., Yuille M.A.R., Dyer M.J.S., Kerckaert J.-P.
The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231).
Leukemia 10:579-587(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-562 - Discontinued
ECACC; 06120601
Cell_Model_Passport; SIDM01017
Cosmic-CLP; 1327774
DepMap; ACH-002255
Ontologies EFO; EFO_0005389
Biological sample resources BioSample; SAMN03473540
Chemistry resources GDSC; 1327774
PharmacoDB; KARPAS231_728_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM115820
GEO; GSM1035318
GEO; GSM1374586
GEO; GSM1374587
GEO; GSM1669974
Other Wikidata; Q54899491
Polymorphism and mutation databases Cosmic; 1281371
Cosmic; 2297008
Progenetix; CVCL_1822
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number27