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Cellosaurus Karpas-231 (CVCL_1822)

Cell line name Karpas-231
Synonyms KARPAS-231; Karpas 231; KARPAS 231; KARPAS231; K231
Accession CVCL_1822
Resource Identification Initiative To cite this cell line use: Karpas-231 (RRID:CVCL_1822)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~30-40 hours (DSMZ); ~60 hours (ECACC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia (ALL-L3).
Derived from sampling site: Peripheral blood.
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,14
D5S81812
D7S8208,9
D13S3178,12
D16S53911,13
TH018,9.3
TPOX8,9
vWA18
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=8324225
Nacheva E., Dyer M.J.S., Fischer P., Stranks G., Heward J.M., Marcus R.E., Grace C., Karpas A.
C-MYC translocations in de novo B-cell lineage acute leukemias with t(14;18) (cell lines Karpas 231 and 353).
Blood 82:231-240(1993)

PubMed=7849311
Stranks G., Height S.E., Mitchell P., Jadayel D., Yuille M.A., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=8618432
Galiegue Zouitina S., Quief S., Hildebrand M.P., Denis C., Lecocq G., Collyn-d'Hooghe M., Bastard C., Yuille M., Dyer M.J.S., Kerckaert J.-P.
The B cell transcriptional coactivator BOB1/OBF1 gene fuses to the LAZ3/BCL6 gene by t(3;11)(q27;q23.1) chromosomal translocation in a B cell leukemia line (Karpas 231).
Leukemia 10:579-587(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections DSMZ; ACC-562 - Discontinued
ECACC; 06120601
Cell line databases/resources CCLE; KARPAS231_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1327774
GDSC; 1327774
LINCS_LDP; LCL-1087
Ontologies EFO; EFO_0005389
Biological sample resources BioSample; SAMN03473540
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM115820
GEO; GSM1035318
GEO; GSM1374586
GEO; GSM1374587
GEO; GSM1669974
Other Wikidata; Q54899491
Polymorphism and mutation databases Cosmic; 1281371
Cosmic; 2297008