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Cellosaurus KYAE-1 (CVCL_1825)

[Text version]

Cell line name KYAE-1
Synonyms KYAE1; KYAE
Accession CVCL_1825
Resource Identification Initiative To cite this cell line use: KYAE-1 (RRID:CVCL_1825)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~3-4 days (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Pro152Leu (c.455C>T) (PubMed=20075370).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.72
East Asian, North76.1
East Asian, South22.17
South Asian0
European, North0
European, South0
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; JCRB; PubMed=20075370

Markers:
AmelogeninX
CSF1PO11
D3S135815,16
D5S81810,13
D7S82011,12
D8S117913,14
D13S31711,12
D16S53911
D18S5114,15
D21S1129,31
FGA18
Penta D9,10
Penta E5,8
TH016
TPOX8
vWA12,14 (DSMZ)
14 (Cosmic-CLP; ECACC; JCRB; PubMed=20075370)

Run an STR similarity search on this cell line
Publications

PubMed=11520067; DOI=10.1006/bbrc.2001.5400
Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
Gene expression profiling in human esophageal cancers using cDNA microarray.
Biochem. Biophys. Res. Commun. 286:792-801(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-703
ECACC; 11012002
JCRB; JCRB1483
Cell line databases/resources CCLE; KYAE1_OESOPHAGUS
Cell_Model_Passport; SIDM00530
Cosmic-CLP; 1503368
DepMap; ACH-001544
Chemistry resources GDSC; 1503368
PharmacoDB; KYAE1_798_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670014
Other Wikidata; Q54900776
Polymorphism and mutation databases Cosmic; 1599341
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number23