Cellosaurus KYAE-1 (CVCL_1825)

Cell line name KYAE-1
Synonyms KYAE
Accession CVCL_1825
Resource Identification Initiative To cite this cell line use: KYAE-1 (RRID:CVCL_1825)
Comments Doubling time: ~3-4 days (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: TP53 p.Pro152Leu (PubMed=20075370).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Esophageal adenocarcinoma (NCIt: C4025)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; JCRB; PubMed=20075370

Markers:
AmelogeninX
CSF1PO11
D13S31711,12
D16S53911
D18S5114,15
D21S1129,31
D3S135815,16
D5S81810,13
D7S82011,12
D8S117913,14
FGA18
Penta D9,10
Penta E5,8
TH016
TPOX8
vWA12,14 (DSMZ)
14 (Cosmic-CLP; ECACC; JCRB; PubMed=20075370)
Publications

PubMed=11520067; DOI=10.1006/bbrc.2001.5400
Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
Gene expression profiling in human esophageal cancers using cDNA microarray.
Biochem. Biophys. Res. Commun. 286:792-801(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-703
ECACC; 11012002
JCRB; JCRB1483
Cell line databases/resources Cosmic-CLP; 1503368
GDSC; 1503368
Gene expression databases GEO; GSM1670014
Polymorphism and mutation databases Cosmic; 1599341