Home  |  Contact

Cellosaurus LA-N-1 (CVCL_1827)

[Text version]

Cell line name LA-N-1
Synonyms LAN-1; LAN1; Lan1
Accession CVCL_1827
Resource Identification Initiative To cite this cell line use: LA-N-1 (RRID:CVCL_1827)
Comments Doubling time: ~100 hours (DSMZ); ~2 days (ECACC).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations ALK p.Phe1174Leu (c.3522C>A) (PubMed=18724359).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2549 (LA1-5s)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): COG; DSMZ; ECACC; RCB

Markers:
AmelogeninX,Y
CSF1PO12
D2S133816,21
D3S135816,16.2
D5S81812
D7S82010 (COG)
10,11 (DSMZ; ECACC; RCB)
D8S117913,14
D13S31711,12
D16S5399
D18S5114
D19S43313
D21S1129,36
FGA19,24
TH018,9.3
TPOX8,11
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=856461
Seeger R.C., Rayner S.A., Banerjee A., Chung H., Laug W.E., Neustein H.B., Benedict W.F.
Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.
Cancer Res. 37:1364-1371(1977)

PubMed=7037175
Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

PubMed=2535691
Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=7838528
Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18165268; DOI=10.2353/ajpath.2008.061263
Stock C., Bozsaky E., Watzinger F., Poetschger U., Orel L., Lion T., Kowalska A., Ambros P.F.
Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization.
Am. J. Pathol. 172:203-214(2008)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

Cross-references
Cell line collections DSMZ; ACC-655
ECACC; 06041201
ICLC; HTL98005 - Discontinued
RCB; RCB0483
Cell line databases/resources TOKU-E; 4118
Ontologies BTO; BTO:0003542
CLO; CLO_0007240
CLO; CLO_0051542
EFO; EFO_0005391
Biological sample resources BioSample; SAMN03472327
BioSample; SAMN03473468
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM313802
GEO; GSM333797
GEO; GSM563355
GEO; GSM692872
GEO; GSM1366408
Other Wikidata; Q54901875
Polymorphism and mutation databases Cosmic; 801740
Cosmic; 920240
Cosmic; 947710
Cosmic; 1019927
Cosmic; 1037343
Cosmic; 1099140
Cosmic; 1109118
Cosmic; 1153781
Cosmic; 1153809
Cosmic; 1161991
Cosmic; 1167411
Cosmic; 1526627
Cosmic; 2131578
Cosmic; 2239461
Cosmic; 2301574
Cosmic; 2393635
Cosmic; 2485946
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-20
Version number24