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Cellosaurus LA-N-2 (CVCL_1829)

Cell line name LA-N-2
Synonyms LAN-2; LAN2
Accession CVCL_1829
Resource Identification Initiative To cite this cell line use: LA-N-2 (RRID:CVCL_1829)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Intermediate type (I-type) (PubMed=15720811).
Doubling time: ~50-70 hours (Note=But longer after recovery from liquid nitrogen freezing) (DSMZ=ACC-671).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg337Cys (c.1009C>T); ClinVar=VCV000142536; Zygosity=Unspecified (DepMap).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): COG; DepMap; DSMZ; ECACC; RCB

Markers:
AmelogeninX
CSF1PO10,12
D2S133820
D3S135815
D5S81811,12
D7S8208,10
D8S117913,15
D13S31711,12
D16S5399,10
D18S5115,18
D19S43314
D21S1129,30
FGA20,22
Penta D11,12
Penta E11,17
TH019.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=856461
Seeger R.C., Rayner S.A., Banerjee A., Chung H., Laug W.E., Neustein H.B., Benedict W.F.
Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines.
Cancer Res. 37:1364-1371(1977)

PubMed=7037175
Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Cancer Res. 42:1331-1336(1982)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=18923524; DOI=10.1038/nature07399
Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M., Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A., Hayashi Y., Mano H., Ogawa S.
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

Cross-references
Cell line collections (Providers) DSMZ; ACC-671
ECACC; 06041202
RCB; RCB0484
Cell line databases/resources CLO; CLO_0050262
cancercelllines; CVCL_1829
Cell_Model_Passport; SIDM01370
DepMap; ACH-001354
DSMZCellDive; ACC-671
Lonza; 1195
Biological sample resources BioSample; SAMN03472328
BioSample; SAMN03473426
Encyclopedic resources Wikidata; Q54901876
Gene expression databases GEO; GSM313803
GEO; GSM333798
Polymorphism and mutation databases Cosmic; 801741
Cosmic; 920241
Cosmic; 947711
Cosmic; 1037344
Cosmic; 1099141
Cosmic; 1109103
Cosmic; 1153782
Cosmic; 1526628
Cosmic; 2131579
Cosmic; 2301575
Cosmic; 2485947
Progenetix; CVCL_1829
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25