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Cellosaurus NALM-21 (CVCL_1837)

[Text version]
Cell line name NALM-21
Synonyms NALM21
Accession CVCL_1837
Resource Identification Initiative To cite this cell line use: NALM-21 (RRID:CVCL_1837)
Comments Population: Japanese.
Doubling time: ~50 hours (DSMZ=ACC-682).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072).
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L054 ! B250
CVCL_1836 ! NALM-20
CVCL_5662 ! NALM-22
CVCL_5663 ! NALM-23
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): DSMZ; JCRB

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,24
D3S135814,15
D5S81811,13
D7S82010,12
D8S117911,16
D13S3178,12
D16S5399,10
D18S5116,17
D19S43313,14
D21S1130,31.2
FGA20,21
Penta D11,13
Penta E9,18
TH019
TPOX8,11
vWA14,18

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Publications

PubMed=1817649
Matsuo Y., Ariyasu T., Ohmoto E., Kimura I., Minowada J.
Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient with acute leukemia: NALM-20, established at the onset; and NALM-21, NALM-22 and NALM-23, established after relapse.
Hum. Cell 4:335-338(1991)

PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x
Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K., Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Leuk. Res. 18:221-228(1994)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=34940123; DOI=10.3390/cimb43030149
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references
Cell line collections (Providers) DSMZ; ACC-682
JCRB; JCRB1825
Cell line databases/resources DSMZCellDive; ACC-682
Encyclopedic resources Wikidata; Q54907402
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Polymorphism and mutation databases Cosmic; 999738
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number20