ID   OACP4 C
AC   CVCL_1843
SY   OAC-P4C; OACP4C; OACp4C
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473391
DR   cancercelllines; CVCL_1843
DR   Cell_Model_Passport; SIDM00445
DR   Cosmic; 1599345
DR   Cosmic-CLP; 1503362
DR   DepMap; ACH-002292
DR   DSMZ; ACC-704
DR   DSMZCellDive; ACC-704
DR   ECACC; 11012005
DR   EGA; EGAS00001000978
DR   GDSC; 1503362
DR   GEO; GSM1670291
DR   PharmacoDB; OACp4C_1177_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54931678
RX   PubMed=11407472;
RX   PubMed=20075370;
RX   PubMed=23795680;
RX   PubMed=27397505;
RX   PubMed=27594985;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~35-50 hours (DSMZ=ACC-704).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln192Ter (c.574C>T); ClinVar=VCV000406579; Zygosity=Homozygous (PubMed=20075370; Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0.19%; Native American=0.55%; East Asian, North=0%; East Asian, South=1.33%; South Asian=0.08%; European, North=66.1%; European, South=31.76% (PubMed=30894373).
CC   Misspelling: OACP4CE; PubMed=23795680.
ST   Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=20075370
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 12,13
ST   D19S433: 15
ST   D21S11: 30
ST   D2S1338: 16,24
ST   D3S1358: 18
ST   D5S818: 9
ST   D7S820: 9,11
ST   D8S1179: 13
ST   FGA: 20
ST   Penta D: 12
ST   Penta E: 20
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4025; Esophageal adenocarcinoma
DI   ORDO; Orphanet_99976; Adenocarcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2249 ! OACM4.1 C
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 33
//
RX   PubMed=11407472; DOI=10.1007/s004280000358;
RA   de Both N.J., Wijnhoven B.P.L., Sleddens H.F.B.M., Tilanus H.W.,
RA   Dinjens W.N.M.;
RT   "Establishment of cell lines from adenocarcinomas of the esophagus and
RT   gastric cardia growing in vivo and in vitro.";
RL   Virchows Arch. 438:451-456(2001).
//
RX   PubMed=20075370; DOI=10.1093/jnci/djp499;
RA   Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P.,
RA   Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K.,
RA   Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H.,
RA   Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.;
RT   "Verification and unmasking of widely used human esophageal
RT   adenocarcinoma cell lines.";
RL   J. Natl. Cancer Inst. 102:271-274(2010).
//
RX   PubMed=23795680; DOI=10.1111/dote.12095;
RA   Boonstra J.J., Tilanus H.W., Dinjens W.N.M.;
RT   "Translational research on esophageal adenocarcinoma: from cell line
RT   to clinic.";
RL   Dis. Esophagus 28:90-96(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=27594985; DOI=10.12688/f1000research.7033.1;
RA   Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J.,
RA   Lynch A.G., Edwards P.A.W., Fitzgerald R.C.;
RT   "Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.";
RL   F1000Research 5:1336.1-1336.12(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//