Cellosaurus RCH-ACV (CVCL_1851)

Cell line name RCH-ACV
Synonyms RCHACV; RCH
Accession CVCL_1851
Resource Identification Initiative To cite this cell line use: RCH-ACV (RRID:CVCL_1851)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 36 hours (PubMed=3455845); ~30-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: RCH-AVC; In Cosmic 1191705.
Derived from sampling site: Bone marrow.
Disease B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_Y458 ! RCH-ADD
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO10,11
D13S3179,14
D16S53911
D5S81811,12
D7S82010,11
TH016,8
TPOX8,11
vWA16,17
Publications

PubMed=3455845; DOI=10.1016/0165-4608(86)90055-5
Jack I., Seshadri R., Garson M., Michael P., Callen D., Zola H., Morley A.
RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.
Cancer Genet. Cytogenet. 19:261-269(1986)

PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z
Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J., Smith S.D., Cleary M.L.
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545(1990)

PubMed=1720549; DOI=10.1073/pnas.88.23.10735
Ziemin-van der Poel S., McCabe N.R., Gill H.J., Espinosa R. III, Patel Y., Harden A., Rubinelli P., Smith S.D., Le Beau M.M., Rowley J.D., Diaz M.O.
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=10490826; DOI=10.1038/sj.onc.1202874
Fu X., McGrath S., Pasillas M., Nakazawa S., Kamps M.P.
EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
Oncogene 18:4920-4929(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16523483; DOI=10.1002/gcc.20317
Horsley S.W., Mackay A., Iravani M., Fenwick K., Valgeirsson H., Dexter T., Ashworth A., Kearney L.
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes Chromosomes Cancer 45:554-564(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-548
Cell line databases/resources CCLE; RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1330994
GDSC; 1330994
IGRhCellID; RCHACV
Ontologies BTO; BTO:0003376
EFO; EFO_0002314
Biological sample resources BioSample; SAMN03473533
Gene expression databases GEO; GSM887525
GEO; GSM888607
GEO; GSM931332
GEO; GSM931333
GEO; GSM931334
GEO; GSM1670365
Polymorphism and mutation databases Cosmic; 1130248
Cosmic; 1191705
Cosmic; 2396141
Cosmic; 2396180
Cosmic; 2427703
Cosmic; 2491074