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Cellosaurus BT-B [Human HeLa contaminated cell line] (CVCL_1858)

[Text version]
Cell line name BT-B [Human HeLa contaminated cell line]
Accession CVCL_1858
Resource Identification Initiative To cite this cell line use: BT-B [Human HeLa contaminated cell line] (RRID:CVCL_1858)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (DSMZ=ACC-227). Originally thought to originate from the a 66 year old Caucasian man with a malignant urinary bladder carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00394.
Population: African American.
Doubling time: ~43 hours (DSMZ=ACC-227).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135815,18
D5S81811,12
D7S8208,12
D8S117912,13
D13S31713.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,17
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=2108047; DOI=10.1016/0014-4827(90)90080-T
van der Bosch J., Ruller S., Horn D., Schumann R., Schlaak M.
Density-dependent tumor cell death and reversible cell cycle arrest: mutually exclusive modes of monocyte-mediated growth control.
Exp. Cell Res. 187:185-192(1990)

PubMed=8230540; DOI=10.1016/S0022-5347(17)35941-4
Bohle A., Thanhauser A., Ulmer A.J., Ernst M., Flad H.-D., Jocham D.
Dissecting the immunobiological effects of Bacillus Calmette-Guerin (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell phenomenon.
J. Urol. 150:1932-1937(1993)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) DSMZ; ACC-227 - Discontinued
Cell line databases/resources CLO; CLO_0002045
CLDB; cl500
DSMZCellDive; ACC-227
Biological sample resources BioSample; SAMN03151668
BioSample; SAMN03470925
Encyclopedic resources Wikidata; Q54798477
Polymorphism and mutation databases Cosmic; 905951
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number26