ID   CCRF-SB
AC   CVCL_1860
SY   CCRF SB; CCRFSB; SB; S.B.; GM04154; GM04154B
DR   CLO; CLO_0002336
DR   CLO; CLO_0016198
DR   EFO; EFO_0006550
DR   CLDB; cl679
DR   CLDB; cl680
DR   CLDB; cl681
DR   ArrayExpress; E-MTAB-2706
DR   ATCC; CCL-120
DR   BioSample; SAMN03471043
DR   BioSample; SAMN03472769
DR   cancercelllines; CVCL_1860
DR   CCRID; 4201HUM-CCTCC00304
DR   CCTCC; GDC0304
DR   ChEMBL-Cells; CHEMBL3307643
DR   ChEMBL-Targets; CHEMBL614542
DR   Coriell; GM04154
DR   Cosmic; 683533
DR   Cosmic; 2301562
DR   Cosmic; 2649231
DR   ECACC; 89090405
DR   EGA; EGAS00001000610
DR   GEO; GSM5137709
DR   IARC_TP53; 21219
DR   IGRhCellID; CCRFSB
DR   IZSLER; BS TCL 12
DR   JCRB; IFO50026
DR   JCRB; JCRB0032
DR   LINCS_LDP; LCL-1006
DR   NCI-DTP; CCRF-SB
DR   PharmacoDB; CCRFSB_191_2019
DR   PRIDE; PXD023662
DR   Progenetix; CVCL_1860
DR   PubChem_Cell_line; CVCL_1860
DR   Wikidata; Q54809040
RX   CelloPub=CLPUB00447;
RX   DOI=10.1007/BF02618370;
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=62390;
RX   PubMed=1086134;
RX   PubMed=3335022;
RX   PubMed=4363409;
RX   PubMed=4523807;
RX   PubMed=4991454;
RX   PubMed=8316623;
RX   PubMed=20215515;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=29892436;
RX   PubMed=35124168;
RX   PubMed=35354797;
CC   Population: Caucasian.
CC   HLA typing: A*01:01,02:01; B*44:05,57:01; C*02:02,06:02 (PubMed=26589293).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): ATCC; JCRB; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 9,13 (ATCC; PubMed=25877200)
ST   D16S539: 13 (JCRB)
ST   D18S51: 9,14
ST   D21S11: 27,28
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 9,15
ST   FGA: 25
ST   Penta D: 9,12
ST   Penta E: 6,13
ST   TH01: 9,10
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1859 ! CCRF-HSB-2
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 32
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=62390; DOI=10.1111/j.1365-3083.1976.tb03029.x;
RA   Yount W.J., Utsinger P.D., Hutt L.M., Buchanan P.D., Korn J.H.,
RA   Fuller C.R., Logue M., Pagano J.S.;
RT   "Subpopulations of human lymphoblastoid cell lines. Correlation with
RT   the expression of surface receptors and content of Epstein-Barr virus
RT   genome.";
RL   Scand. J. Immunol. 5:795-810(1976).
//
RX   PubMed=1086134;
RA   Kaplan J., Peterson W.D. Jr.;
RT   "Detection of T-cell lymphoma-associated antigens on cord blood
RT   lymphocytes and phytohemagglutinin-stimulated blasts.";
RL   Cancer Res. 36:3471-3475(1976).
//
RX   PubMed=3335022;
RA   Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J.,
RA   Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.;
RT   "Feasibility of drug screening with panels of human tumor cell lines
RT   using a microculture tetrazolium assay.";
RL   Cancer Res. 48:589-601(1988).
//
RX   PubMed=4363409; DOI=10.1084/jem.139.5.1070;
RA   Kaplan J., Shope T.C., Peterson W.D. Jr.;
RT   "Epstein-Barr virus-negative human malignant T-cell lines.";
RL   J. Exp. Med. 139:1070-1076(1974).
//
RX   PubMed=4523807; DOI=10.1007/BF02616012;
RA   Lazarus H., Barell E.F., Oppenheim S.O., Krishan A.;
RT   "Divergent properties of two human lymphocytic cell lines isolated
RT   from a single specimen of peripheral blood.";
RL   In Vitro 9:303-310(1974).
//
RX   PubMed=4991454; DOI=10.1016/0014-4827(79)90504-4;
RA   Adams R.A., Pothier L., Flowers A., Lazarus H., Farber S., Foley G.E.;
RT   "The question of stemlines in human acute leukemia. Comparison of
RT   cells isolated in vitro and in vivo from a patient with acute
RT   lymphoblastic leukemia.";
RL   Exp. Cell Res. 62:5-10(1970).
//
RX   PubMed=8316623; DOI=10.2307/3578190;
RA   Evans H.H., Ricanati M., Horng M.-F., Jiang Q.-Y., Mencl J.,
RA   Olive P.L.;
RT   "DNA double-strand break rejoining deficiency in TK6 and other human
RT   B-lymphoblast cell lines.";
RL   Radiat. Res. 134:307-315(1993).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5;
RA   Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T.,
RA   Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E.,
RA   Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I.,
RA   Lehtio J., Vesterlund M., Jafari R.;
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//