Home  |  Contact

Cellosaurus MEC-2 (CVCL_1871)

[Text version]

Cell line name MEC-2
Synonyms MEC2
Accession CVCL_1871
Resource Identification Initiative To cite this cell line use: MEC-2 (RRID:CVCL_1871)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 31 hours (PubMed=10071128); ~40-50 hours (DSMZ).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.35
Native American0
East Asian, North2.58
East Asian, South0
South Asian5.1
European, North25.37
European, South65.6
Disease Chronic lymphocytic leukemia (NCIt: C3163)
B-cell chronic lymphocytic leukemia (ORDO: Orphanet_67038)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1870 ! MEC-1
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81810,12
D7S8207,11
D13S31711,12
D16S5399,11
TH016,8
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=10071128; DOI=10.1016/S0145-2126(98)00154-4
Stacchini A., Aragno M., Vallario A., Alfarano A., Circosta P., Gottardi D., Faldella A., Rege-Cambrin G., Thunberg U., Nilsson K., Caligaris-Cappio F.
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.
Leuk. Res. 23:127-136(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Lanemo Myhrinder A., Hellqvist E., Bergh A.-C., Jansson M., Nilsson K., Hultman P., Jonasson J., Buhl A.M., Bredo Pedersen L., Jurlander J., Klein E., Weit N., Herling M., Rosenquist R., Rosen A.
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

PubMed=25162594; DOI=10.1371/journal.pone.0106008
Rasul E., Salamon D., Nagy N., Leveau B., Banati F., Szenthe K., Koroknai A., Minarovits J., Klein G., Klein E.
The MEC1 and MEC2 lines represent two CLL subclones in different stages of progression towards prolymphocytic leukemia.
PLoS ONE 9:E106008-E106008(2014)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-500
Cell line databases/resources CCLE; MEC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00827
DepMap; ACH-001121
LINCS_LDP; LCL-1090
Lonza; 1161
Ontologies BTO; BTO:0005914
EFO; EFO_0006285
Chemistry resources PharmacoDB; MEC2_912_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM887306
GEO; GSM888382
GEO; GSM1374668
GEO; GSM1670092
Other Wikidata; Q54904996
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number25