Cellosaurus MEC-2 (CVCL_1871)

Cell line name MEC-2
Synonyms MEC2
Accession CVCL_1871
Resource Identification Initiative To cite this cell line use: MEC-2 (RRID:CVCL_1871)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 31 hours (PubMed=10071128); ~40-50 hours (DSMZ).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Chronic lymphocytic leukemia (NCIt: C3163)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1870 ! MEC-1
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S31711,12
D16S5399,11
D5S81810,12
D7S8207,11
TH016,8
TPOX8,11
vWA16,17
Publications

PubMed=10071128; DOI=10.1016/S0145-2126(98)00154-4
Stacchini A., Aragno M., Vallario A., Alfarano A., Circosta P., Gottardi D., Faldella A., Rege-Cambrin G., Thunberg U., Nilsson K., Caligaris-Cappio F.
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.
Leuk. Res. 23:127-136(1999)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Lanemo Myhrinder A., Hellqvist E., Bergh A.-C., Jansson M., Nilsson K., Hultman P., Jonasson J., Buhl A.M., Bredo Pedersen L., Jurlander J., Klein E., Weit N., Herling M., Rosenquist R., Rosen A.
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

Cross-references
Cell line collections DSMZ; ACC-500
Cell line databases/resources CCLE; MEC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
LINCS_LDP; LCL-1090
Ontologies BTO; BTO:0005914
EFO; EFO_0006285
Gene expression databases GEO; GSM887306
GEO; GSM888382
GEO; GSM1374668
GEO; GSM1670092