ID   MEC-2
AC   CVCL_1871
SY   MEC2
DR   BTO; BTO:0005914
DR   CLO; CLO_0037182
DR   EFO; EFO_0006285
DR   ArrayExpress; E-MTAB-3610
DR   cancercelllines; CVCL_1871
DR   Cell_Model_Passport; SIDM00827
DR   DepMap; ACH-001121
DR   DSMZ; ACC-500
DR   DSMZCellDive; ACC-500
DR   EGA; EGAS00001000978
DR   GEO; GSM887306
DR   GEO; GSM888382
DR   GEO; GSM1374668
DR   GEO; GSM1670092
DR   IARC_TP53; 30120
DR   LINCS_LDP; LCL-1090
DR   Lonza; 1161
DR   PharmacoDB; MEC2_912_2019
DR   Progenetix; CVCL_1871
DR   Wikidata; Q54904996
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=10071128;
RX   PubMed=19358282;
RX   PubMed=20454443;
RX   PubMed=22460905;
RX   PubMed=23297799;
RX   PubMed=25162594;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 31 hours (PubMed=10071128); ~40-50 hours (DSMZ=ACC-500).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=1.35%; Native American=0%; East Asian, North=2.58%; East Asian, South=0%; South Asian=5.1%; European, North=25.37%; European, South=65.6% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 12,14
ST   D21S11: 27,29
ST   D2S1338: 16,19
ST   D3S1358: 15,19
ST   D5S818: 10,12
ST   D7S820: 7,11
ST   D8S1179: 13
ST   FGA: 21,25
ST   Penta D: 11,17
ST   Penta E: 10,12
ST   TH01: 6,8
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3163; Chronic lymphocytic leukemia
DI   ORDO; Orphanet_67038; B-cell chronic lymphocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1870 ! MEC-1
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 32
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=10071128; DOI=10.1016/S0145-2126(98)00154-4;
RA   Stacchini A., Aragno M., Vallario A., Alfarano A., Circosta P.,
RA   Gottardi D., Faldella A., Rege-Cambrin G., Thunberg U., Nilsson K.,
RA   Caligaris-Cappio F.;
RT   "MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic
RT   leukaemia in prolymphocytoid transformation.";
RL   Leuk. Res. 23:127-136(1999).
//
RX   PubMed=19358282; DOI=10.1002/ijc.24351;
RA   Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M.,
RA   Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.;
RT   "Expression of the ULBP ligands for NKG2D by B-NHL cells plays an
RT   important role in determining their susceptibility to
RT   rituximab-induced ADCC.";
RL   Int. J. Cancer 125:212-221(2009).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767;
RA   Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.;
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23297799; DOI=10.3109/10428194.2013.764418;
RA   Myhrinder A.L., Hellqvist E., Bergh A.-C., Jansson M.,
RA   Nilsson K., Hultman P., Jonasson J., Buhl A.M., Pedersen L.B.,
RA   Jurlander J., Klein E., Weit N., Herling M., Rosenquist R., Rosen A.;
RT   "Molecular characterization of neoplastic and normal 'sister'
RT   lymphoblastoid B-cell lines from chronic lymphocytic leukemia.";
RL   Leuk. Lymphoma 54:1769-1779(2013).
//
RX   PubMed=25162594; DOI=10.1371/journal.pone.0106008;
RA   Rasul E., Salamon D., Nagy N., Leveau B., Banati F., Szenthe K.,
RA   Koroknai A., Minarovits J., Klein G., Klein E.;
RT   "The MEC1 and MEC2 lines represent two CLL subclones in different
RT   stages of progression towards prolymphocytic leukemia.";
RL   PLoS ONE 9:E106008-E106008(2014).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//