ID   MUTZ-5
AC   CVCL_1873
SY   Mutz-5; MUTZ5; Menschliche Und Tierische Zellkulture-5
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03473564
DR   BioSample; SAMN10988511
DR   CCLE; MUTZ5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   Cosmic; 1130257
DR   Cosmic; 1278371
DR   Cosmic; 1519165
DR   Cosmic; 1524809
DR   DepMap; ACH-000492
DR   DSMZ; ACC-490
DR   GEO; GSM887343
DR   GEO; GSM888419
DR   LiGeA; CCLE_431
DR   PharmacoDB; MUTZ5_971_2019
DR   Progenetix; CVCL_1873
DR   Wikidata; Q54907101
RX   DOI=10.1007/978-3-642-59358-1_5;
RX   PubMed=11516110;
RX   PubMed=15843827;
RX   PubMed=22460905;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Doubling time: ~70-100 hours (DOI=10.1007/978-3-642-59358-1_5; DSMZ).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=16.18%; Native American=0.51%; East Asian, North=0%; East Asian, South=2.27%; South Asian=12.13%; European, North=13.74%; European, South=55.18% (PubMed=30894373).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): DSMZ
ST   Amelogenin: X
ST   CSF1PO: 8,9
ST   D13S317: 10,12
ST   D16S539: 10
ST   D5S818: 11
ST   D7S820: 10
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C8644; B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_L068 ! MUTZ-6
OI   CVCL_L069 ! MUTZ-7
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 22
//
RX   DOI=10.1007/978-3-642-59358-1_5;
RA   Meyer C., MacLeod R.A.F., Quentmeier H., Janssen J.W.G.,
RA   Coignet L.J.A., Drexler H.G.;
RT   "Establishment of the B-cell precursor-acute lymphoblastic leukemia
RT   cell line MUTZ-5 carrying a (12:13) translocation.";
RL   (In) Acute leukemias IX. Haematology and blood transfusion, Vol. 41; Hiddemann W., Haferlach T., Unterhalt M., Buechner T., Ritter J. (eds.); pp.15-18; Springer; Berlin (2003).
//
RX   PubMed=11516110; DOI=10.1038/sj.leu.2402212;
RA   Meyer C., MacLeod R.A.F., Quentmeier H., Janssen J.W.G.,
RA   Coignet L.J.A., Dyer M.J.S., Drexler H.G.;
RT   "Establishment of the B cell precursor acute lymphoblastic leukemia
RT   cell line MUTZ-5 carrying a (12:13) translocation.";
RL   Leukemia 15:1471-1474(2001).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J.,
RA   Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M.,
RA   Fioretos T.;
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//