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Cellosaurus ONCO-DG-1 (CVCL_1882)

[Text version]

Cell line name ONCO-DG-1
Synonyms ONCO-DG 1; ONCO-DG1; ONCODG1
Accession CVCL_1882
Resource Identification Initiative To cite this cell line use: ONCO-DG-1 (RRID:CVCL_1882)
Comments Problematic cell line: Contaminated. Shown to be a OVCAR-3 derivative (PubMed=20143388). Originally thought to originate from a 49 year old female patient with a thyroid gland papillary carcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00338.
Doubling time: ~30 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Homozygous for TP53 p.Arg248Gln (c.743G>A) (PubMed=14522906).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North4.26
East Asian, South0
South Asian0
European, North61.21
European, South34.52
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010
D13S31712
D16S53912
TH019,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=1381131; DOI=10.1007/BF02899670
Grimm D., Hofstadter F., Bauer J., Spruss T., Steinbach P., Bernhardt G., Menze R.
Establishment and characterization of a human papillary thyroid carcinoma cell line with oxyphilic differentiation (ONCO-DG 1).
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 62:97-104(1992)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=23839242; DOI=10.1038/ncomms3126
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126-2126(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-507
Cell line databases/resources CCLE; ONCODG1_OVARY
Cell_Model_Passport; SIDM00093
DepMap; ACH-000013
Ontologies BTO; BTO:0004847
Biological sample resources BioSample; SAMN03151879
BioSample; SAMN10988512
Chemistry resources PharmacoDB; ONCODG1_1200_2019
Gene expression databases ArrayExpress; E-MTAB-2770
Other Wikidata; Q54936399
Polymorphism and mutation databases IARC_TP53; 27010
LiGeA; CCLE_540
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23