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Cellosaurus ONCO-DG-1 (CVCL_1882)

Cell line name ONCO-DG-1
Synonyms ONCO-DG 1; ONCO-DG1; ONCODG1
Accession CVCL_1882
Resource Identification Initiative To cite this cell line use: ONCO-DG-1 (RRID:CVCL_1882)
Comments Problematic cell line: Contaminated. Shown to be a OVCAR-3 derivative (PubMed=20143388). Originally thought to originate from a 49 year old female patient with a thyroid gland papillary carcinoma.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00338.
Doubling time: ~30 hours (DSMZ).
Omics: Deep RNAseq analysis.
Sequence variations Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010
D13S31712
D16S53912
TH019,9.3
TPOX8
vWA17
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=1381131; DOI=10.1007/BF02899670
Grimm D., Hofstadter F., Bauer J., Spruss T., Steinbach P., Bernhardt G., Menze R.
Establishment and characterization of a human papillary thyroid carcinoma cell line with oxyphilic differentiation (ONCO-DG 1).
Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 62:97-104(1992)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=23839242; DOI=10.1038/ncomms3126
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126-2126(2013)

Cross-references
Cell line collections DSMZ; ACC-507
Cell line databases/resources CCLE; ONCODG1_OVARY
Ontologies BTO; BTO:0004847
Biological sample resources BioSample; SAMN03151879
Gene expression databases ArrayExpress; E-MTAB-2770
Other Wikidata; Q54936399