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Cellosaurus RC-K8 (CVCL_1883)

[Text version]

Cell line name RC-K8
Synonyms RCK-8; RCK8; Rck8
Accession CVCL_1883
Resource Identification Initiative To cite this cell line use: RC-K8 (RRID:CVCL_1883)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 48-60 hours (PubMed=3918906); ~36 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Was originally classified as originating from a histiocytic lymphoma.
Derived from sampling site: Peritoneal effusion.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.19
East Asian, North73.44
East Asian, South24.52
South Asian0.79
European, North0.06
European, South0
Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; JCRB

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811 (Cosmic-CLP; DSMZ)
10,11 (JCRB)
D7S82011,12 (Cosmic-CLP; DSMZ)
10.3,12 (JCRB)
D13S3179
D16S53910
TH017
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=3918906; DOI=10.20772/cancersci1985.76.1_12
Kubonishi I., Niiya K., Miyoshi I.
Establishment of a new human lymphoma line that secretes plasminogen activator.
Jpn. J. Cancer Res. 76:12-15(1985)

PubMed=1720549; DOI=10.1073/pnas.88.23.10735
Ziemin-van der Poel S., McCabe N.R., Gill H.J., Espinosa R. III, Patel Y., Harden A., Rubinelli P., Smith S.D., Le Beau M.M., Rowley J.D., Diaz M.O.
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991)

PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L
Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y., Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T., Ueda R., Nakazawa S.
Phenotypic and genotypic characterization of 14 leukemia and lymphoma cell lines with 11q23 translocations.
Leuk. Res. 16:1155-1163(1992)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=23292937; DOI=10.1073/pnas.1205299110
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M.B., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D.B., Dave S.S.
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-561
JCRB; JCRB1334
JCRB; NIHS0537 - Discontinued
Cell line databases/resources CCLE; RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00448
Cosmic-CLP; 1330995
DepMap; ACH-001638
GDSC; 1330995
LINCS_LDP; LCL-1950
Ontologies EFO; EFO_0006742
Biological sample resources BioSample; SAMN03473539
Chemistry resources PharmacoDB; RCK8_1285_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM119551
GEO; GSM380142
GEO; GSM1035315
GEO; GSM1374845
GEO; GSM1670366
Other Wikidata; Q54949416
Polymorphism and mutation databases Cosmic; 1289990
Cosmic; 1517655
Cosmic; 1541907
Cosmic; 1945188
Cosmic; 2276319
Cosmic; 2297020
Cosmic; 2437319
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25