ID   RC-K8
AC   CVCL_1883
SY   RCK-8; RCK8; Rck8
DR   EFO; EFO_0006742
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473539
DR   CCLE; RCK8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   Cell_Model_Passport; SIDM00448
DR   Cosmic; 1289990
DR   Cosmic; 1517655
DR   Cosmic; 1541907
DR   Cosmic; 1945188
DR   Cosmic; 2276319
DR   Cosmic; 2297020
DR   Cosmic; 2437319
DR   Cosmic-CLP; 1330995
DR   DepMap; ACH-001638
DR   DSMZ; ACC-561
DR   GDSC; 1330995
DR   GEO; GSM119551
DR   GEO; GSM380142
DR   GEO; GSM1035315
DR   GEO; GSM1374845
DR   GEO; GSM1670366
DR   JCRB; JCRB1334
DR   JCRB; NIHS0537
DR   LINCS_LDP; LCL-1950
DR   PharmacoDB; RCK8_1285_2019
DR   Progenetix; CVCL_1883
DR   Wikidata; Q54949416
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1465024;
RX   PubMed=1720549;
RX   PubMed=3918906;
RX   PubMed=9738977;
RX   PubMed=16960149;
RX   PubMed=19278952;
RX   PubMed=23292937;
RX   PubMed=25485619;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Japanese.
CC   Doubling time: 48-60 hours (PubMed=3918906); ~36 hours (DSMZ).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=1.19%; East Asian, North=73.44%; East Asian, South=24.52%; South Asian=0.79%; European, North=0.06%; European, South=0% (PubMed=30894373).
CC   Caution: Was originally classified as originating from a histiocytic lymphoma.
CC   Discontinued: JCRB; NIHS0537; true.
CC   Derived from sampling site: Peritoneal effusion.
ST   Source(s): Cosmic-CLP; DepMap; DSMZ; JCRB
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 9
ST   D16S539: 10
ST   D18S51: 16,19
ST   D21S11: 28,30
ST   D3S1358: 15,16
ST   D5S818: 10,11 (JCRB)
ST   D5S818: 11 (Cosmic-CLP; DepMap; DSMZ)
ST   D7S820: 10.3,12 (DepMap; JCRB)
ST   D7S820: 11,12 (Cosmic-CLP; DSMZ)
ST   D8S1179: 14,15
ST   FGA: 23.2,24
ST   Penta D: 9,11
ST   Penta E: 14
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18,19
DI   NCIt; C36080; Diffuse large B-cell lymphoma germinal center B-cell type
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 29
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L;
RA   Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y.,
RA   Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T.,
RA   Ueda R., Nakazawa S.;
RT   "Phenotypic and genotypic characterization of 14 leukemia and lymphoma
RT   cell lines with 11q23 translocations.";
RL   Leuk. Res. 16:1155-1163(1992).
//
RX   PubMed=1720549; DOI=10.1073/pnas.88.23.10735;
RA   Ziemin-van der Poel S., McCabe N.R., Gill H.J., Espinosa R. III,
RA   Patel Y., Harden A., Rubinelli P., Smith S.D., Le Beau M.M.,
RA   Rowley J.D., Diaz M.O.;
RT   "Identification of a gene, MLL, that spans the breakpoint in 11q23
RT   translocations associated with human leukemias.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).
//
RX   PubMed=3918906; DOI=10.20772/cancersci1985.76.1_12;
RA   Kubonishi I., Niiya K., Miyoshi I.;
RT   "Establishment of a new human lymphoma line that secretes plasminogen
RT   activator.";
RL   Jpn. J. Cancer Res. 76:12-15(1985).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R.,
RA   Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M.,
RA   Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F.,
RA   Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S.,
RA   Martinez-Climent J.A.;
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=19278952; DOI=10.1182/blood-2009-01-202028;
RA   Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C.,
RA   Robetorye R.S., Aguiar R.C.T.;
RT   "Copy number abnormalities, MYC activity, and the genetic fingerprint
RT   of normal B cells mechanistically define the microRNA profile of
RT   diffuse large B-cell lymphoma.";
RL   Blood 113:6681-6690(2009).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110;
RA   Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L.,
RA   Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G.,
RA   Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P.,
RA   Flowers C.R., Naresh K., Evens A.M., Gordon L.I., Czader M.B., Gill J.I.,
RA   Hsi E.D., Liu Q.-Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J.,
RA   Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S.,
RA   Dunson D.B., Dave S.S.;
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//