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Cellosaurus RO (CVCL_1886)

[Text version]
Cell line name RO
Synonyms Ro; Robert
Accession CVCL_1886
Resource Identification Initiative To cite this cell line use: RO (RRID:CVCL_1886)
Comments Doubling time: ~50-60 hours (DSMZ=ACC-452).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 9986; RFX5; Simple; p.Arg294Ter (c.880C>T); ClinVar=VCV001431893; Zygosity=Homozygous (PubMed=7744245).
  • Mutation; HGNC; 9986; RFX5; Simple; p.Pro409Arg (c.1226C>G); ClinVar=VCV000292612; Zygosity=Homozygous (PubMed=7744245).
Disease Bare lymphocyte syndrome type 2 (NCIt: C171268)
Immunodeficiency by defective expression of MHC class II (ORDO: Orphanet_572)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y
Category Transformed cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133820,21
D3S135814,15
D5S81812,13
D7S82011,12
D8S117913,14
D13S31711,12
D16S53910,12
D18S5114,15
D19S43314
D21S1128,29
FGA19,23
Penta D9,12
Penta E12,16
TH017,8
TPOX8,10
vWA17,18

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Publications

PubMed=3133120; DOI=10.1016/s0092-8674(88)90389-3
Reith W., Satola S., Herrero Sanchez C., Amaldi I., Lisowska-Grospierre B., Griscelli C., Hadam M.R., Mach B.
Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.
Cell 53:897-906(1988)

PubMed=7744245; DOI=10.1101/gad.9.9.1021
Steimle V., Durand B., Barras E., Zufferey M., Hadam M.R., Mach B., Reith W.
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).
Genes Dev. 9:1021-1032(1995)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

Cross-references
Cell line collections (Providers) DSMZ; ACC-452
Cell line databases/resources DSMZCellDive; ACC-452
Biological sample resources BioSample; SAMN03473551
Encyclopedic resources Wikidata; Q54950785
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number16