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Cellosaurus ROS-50 (CVCL_1887)

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Cell line name ROS-50
Synonyms Ros-50; ROS.50; ROS 50; Ros 50; ROS50; Ros50; Rotterdam Suspension cell line no. 50
Accession CVCL_1887
Resource Identification Initiative To cite this cell line use: ROS-50 (RRID:CVCL_1887)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~50 hours (DSMZ=ACC-557).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.07
East Asian, North0.46
East Asian, South0
South Asian1.38
European, North66.51
European, South31.58
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,26
D3S135814,16
D5S81811
D7S82010,11
D8S117910,15
D13S3178,13
D16S5398,12
D18S5114,15
D19S43315,16
D21S1129,31
FGA24,26
Penta D10
Penta E11,12
TH016,9.3
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=8019967; DOI=10.1016/0165-4608(94)90003-5
van Ooteghem R.B.C., Smit E.M.E., Beishuizen A., Lambrechts A.C., van der Blij-Philipsen M., Smilde T.J., Hagemeijer A.
A new B-cell line showing a complex translocation (8;14;18) and BCL2 rearrangement.
Cancer Genet. Cytogenet. 74:87-94(1994)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-557
Cell line databases/resources CLO; CLO_0037188
cancercelllines; CVCL_1887
Cell_Model_Passport; SIDM00415
Cosmic-CLP; 1331025
DepMap; ACH-001639
DSMZCellDive; ACC-557
LINCS_LDP; LCL-1094
Biological sample resources BioSample; SAMN03473536
CRISP screens repositories BioGRID_ORCS_Cell_line; 1002
Chemistry resources GDSC; 1331025
PharmacoDB; ROS50_1323_2019
Encyclopedic resources Wikidata; Q54950834
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM119485
GEO; GSM1035323
GEO; GSM1670385
Polymorphism and mutation databases Cosmic; 2297010
Progenetix; CVCL_1887
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number35