Cellosaurus ROS-50 (CVCL_1887)

Cell line name ROS-50
Synonyms Ros-50; ROS.50; ROS 50; Ros 50; ROS50; Ros50; Rotterdam Suspension cell line no. 50
Accession CVCL_1887
Resource Identification Initiative To cite this cell line use: ROS-50 (RRID:CVCL_1887)
Comments Part of: COSMIC cell lines project.
Doubling time: ~50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia (ALL-L3).
Derived from sampling site: Peripheral blood.
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3178,13
D16S5398,12
D5S81811
D7S82010,11
TH016,9.3
TPOX11
vWA17,18
Publications

PubMed=8019967; DOI=10.1016/0165-4608(94)90003-5
van Ooteghem R.B.C., Smit E.M.E., Beishuizen A., Lambrechts A.C., van der Blij-Philipsen M., Smilde T.J., Hagemeijer A.
A new B-cell line showing a complex translocation (8;14;18) and BCL2 rearrangement.
Cancer Genet. Cytogenet. 74:87-94(1994)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F., Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma. 57:1015-1020(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-557
Cell line databases/resources Cosmic-CLP; 1331025
GDSC; 1331025
LINCS_LDP; LCL-1094
Biological sample resources BioSample; SAMN03473536
Gene expression databases GEO; GSM119485
GEO; GSM1035323
GEO; GSM1670385
Polymorphism and mutation databases Cosmic; 2297010