ID   ROS-50
AC   CVCL_1887
SY   Ros-50; ROS.50; ROS 50; Ros 50; ROS50; Ros50; Rotterdam Suspension cell line no. 50
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473536
DR   Cell_Model_Passport; SIDM00415
DR   Cosmic; 2297010
DR   Cosmic-CLP; 1331025
DR   DepMap; ACH-001639
DR   DSMZ; ACC-557
DR   EGA; EGAS00001000978
DR   GDSC; 1331025
DR   GEO; GSM119485
DR   GEO; GSM1035323
DR   GEO; GSM1670385
DR   LINCS_LDP; LCL-1094
DR   PharmacoDB; ROS50_1323_2019
DR   Progenetix; CVCL_1887
DR   Wikidata; Q54950834
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8019967;
RX   PubMed=16960149;
RX   PubMed=26727417;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Doubling time: ~50 hours (DSMZ).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=0.07%; East Asian, North=0.46%; East Asian, South=0%; South Asian=1.38%; European, North=66.51%; European, South=31.58% (PubMed=30894373).
CC   Miscellaneous: Originally assigned to be from a B-cell acute lymphoblastic leukemia (ALL-L3).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): Cosmic-CLP; DepMap; DSMZ
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,13
ST   D16S539: 8,12
ST   D18S51: 14,15
ST   D21S11: 29,31
ST   D3S1358: 14,16
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 10,15
ST   FGA: 24,26
ST   Penta D: 10
ST   Penta E: 11,12
ST   TH01: 6,9.3
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C8851; Diffuse large B-cell lymphoma
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 16-12-21; Version: 29
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=8019967; DOI=10.1016/0165-4608(94)90003-5;
RA   van Ooteghem R.B.C., Smit E.M.E., Beishuizen A., Lambrechts A.C.,
RA   van der Blij-Philipsen M., Smilde T.J., Hagemeijer A.;
RT   "A new B-cell line showing a complex translocation (8;14;18) and BCL2
RT   rearrangement.";
RL   Cancer Genet. Cytogenet. 74:87-94(1994).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R.,
RA   Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M.,
RA   Rosenwald A., Sugimoto K.-J., Wheat L.M., Karran E.L., Garcia J.F.,
RA   Sanchez L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S.,
RA   Martinez-Climent J.A.;
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=26727417; DOI=10.3109/10428194.2015.1108414;
RA   Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for double-hit
RT   B-cell lymphomas.";
RL   Leuk. Lymphoma 57:1015-1020(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//