AC   CVCL_1905
AS   CVCL_2900
SY   FL*; FL (HeLa derivative)
DR   BTO; BTO:0003130
DR   CLO; CLO_0003358
DR   CLDB; cl1365
DR   CLDB; cl1366
DR   CLDB; cl1367
DR   BioSample; SAMN03151695
DR   ECACC; 90111910
DR   TOKU-E; 1269
DR   Wikidata; Q54834949
RX   DOI=10.1007/978-1-4757-1647-4_13;
RX   PubMed=1246601;
RX   PubMed=5668122;
RX   PubMed=8397027;
RX   PubMed=13408317;
RX   PubMed=20143388;
RX   PubMed=23925245;
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388). Originally thought to originate from a normal amnion.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00046.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Genome sequenced (low read coverage).
CC   Discontinued: JCRB; JCRB9016; true.
ST   Source(s): ATCC; ECACC
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12,13.3 (ATCC)
ST   D13S317: 12,14 (ECACC)
ST   D16S539: 9,10
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-07-20; Version: 21
RX   DOI=10.1007/978-1-4757-1647-4_13;
RA   Biedler J.L.;
RT   "Chromosome abnormalities in human tumor cells in culture.";
RL   (In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975).
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees W.A., Flandermeyer R.R.;
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
RX   PubMed=5668122; DOI=10.3181/00379727-128-33119;
RA   Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.;
RT   "Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures
RT   determined by sucrose-agar gel and cellulose acetate zymograms.";
RL   Proc. Soc. Exp. Biol. Med. 128:772-776(1968).
RX   PubMed=8397027;
RA   Ogura H., Yoshinouchi M., Kudo T., Imura M., Fujiwara T., Yabe Y.;
RT   "Human papillomavirus type 18 DNA in so-called HEP-2, KB and FL
RT   cells -- further evidence that these cells are HeLa cell derivatives.";
RL   Cell. Mol. Biol. 39:463-467(1993).
RX   PubMed=13408317; DOI=10.3181/00379727-94-23003;
RA   Fogh J., Lund R.O.;
RT   "Continuous cultivation of epithelial cell strain (FL) from human
RT   amniotic membrane.";
RL   Proc. Soc. Exp. Biol. Med. 94:532-537(1957).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=23925245; DOI=10.1038/nature12064;
RA   Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P.,
RA   Martin B.K., Qiu R., Lee C., Shendure J.;
RT   "The haplotype-resolved genome and epigenome of the aneuploid HeLa
RT   cancer cell line.";
RL   Nature 500:207-211(2013).