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Cellosaurus A2780ADR (CVCL_1941)

[Text version]

Cell line name A2780ADR
Synonyms A2780-ADR; A2780 ADR
Accession CVCL_1941
Resource Identification Initiative To cite this cell line use: A2780ADR (RRID:CVCL_1941)
Comments Part of: OCCP ovarian cancer cell line panel.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations ATM p.Pro604Ser (c.1810C>T) (from parent cell line).
PTEN p.Lys128_Arg130del (c.383_391del9) (PubMed=25230021).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=11416159; PubMed=25230021

Markers:
AmelogeninX
CSF1PO10,11
D2S133821,22
D3S135814,16
D5S81811,12
D7S82010
D8S117915,16,17 (PubMed=11416159)
14,15,16,17 (PubMed=25230021)
D13S31713
D16S53911,14
D18S5115
D19S43312
D21S1128
FGA19,25
Penta D8,9
Penta E10,13
TH016 (ECACC; PubMed=25230021)
6,9.3 (PubMed=11416159)
TPOX8,9
vWA15,16

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Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25230021; DOI=10.1371/journal.pone.0103988
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

Cross-references
Cell line collections ECACC; 93112520
Ximbio; 152707
Cell line databases/resources Cell_Model_Passport; SIDM01211
LINCS_LDP; LCL-1694
Ontologies CLO; CLO_0001572
Gene expression databases GEO; GSM827329
GEO; GSM1291127
Other Wikidata; Q54606613
Polymorphism and mutation databases Cosmic; 1139224