ID   Ben-Men-1
AC   CVCL_1959
SY   BEN-MEN-1; BenMen 1; Benign-Meningioma-1
DR   BTO; BTO:0004399
DR   BioSample; SAMN03473495
DR   DSMZ; ACC-599
DR   DSMZCellDive; ACC-599
DR   Wikidata; Q54795998
RX   PubMed=15965488;
RX   PubMed=23151902;
RX   PubMed=28552950;
CC   Doubling time: 25.6 hours (PubMed=15965488); ~40-50 hours (DSMZ=ACC-599).
CC   Sequence variation: Mutation; HGNC; 7773; NF2; Simple; p.Leu214fs*6 (c.640delC); Zygosity=Hemizygous (PubMed=23151902; PubMed=28552950).
CC   Transfected with: HGNC; 11730; TERT.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Deep exome analysis.
CC   Derived from site: In situ; Brain, falx cerebri; UBERON=UBERON_0006059.
ST   Source(s): DSMZ
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 13
ST   D18S51: 14,17
ST   D19S433: 14,15
ST   D21S11: 29,32.2
ST   D2S1338: 20,25
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 9
ST   D8S1179: 11,12
ST   FGA: 21,22
ST   Penta D: 10,11
ST   Penta E: 10,11
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C4329; Meningothelial meningioma
DI   ORDO; Orphanet_2495; Meningioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   68Y
CA   Telomerase immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 22
//
RX   PubMed=15965488; DOI=10.1038/labinvest.3700307;
RA   Puttmann S., Senner V., Braune S., Hillmann B., Exeler R.,
RA   Rickert C.H., Paulus W.;
RT   "Establishment of a benign meningioma cell line by hTERT-mediated
RT   immortalization.";
RL   Lab. Invest. 85:1163-1171(2005).
//
RX   PubMed=23151902; DOI=10.1158/0008-5472.CAN-12-1888;
RA   Burns S.S., Akhmametyeva E.M., Oblinger J.L., Bush M.L., Huang J.,
RA   Senner V., Chen C.-S., Jacob A., Welling D.B., Chang L.-S.;
RT   "Histone deacetylase inhibitor AR-42 differentially affects cell-cycle
RT   transit in meningeal and meningioma cells, potently inhibiting
RT   NF2-deficient meningioma growth.";
RL   Cancer Res. 73:792-803(2013).
//
RX   PubMed=28552950; DOI=10.1371/journal.pone.0178322;
RA   Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y., Beroukhim R., Dunn G.P.,
RA   Dunn I.F.;
RT   "Genomic profile of human meningioma cell lines.";
RL   PLoS ONE 12:E0178322-E0178322(2017).
//