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Cellosaurus C-433 (CVCL_1969)

[Text version]

Cell line name C-433
Synonyms C433
Accession CVCL_1969
Resource Identification Initiative To cite this cell line use: C-433 (RRID:CVCL_1969)
Comments Problematic cell line: Contaminated. Shown to be a RD-ES derivative (DSMZ ACC-268). Originally thought to originate from a 35 year old female patient with a benign giant cell tumor of the right distal tibia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00395.
Population: Caucasian.
Doubling time: ~25-30 hours (DSMZ).
Derived from sampling site: Bone; humerus.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2169 (RD-ES)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11
D5S81811
D7S82010
D13S31711
D16S53911
TH017
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx
Publications

PubMed=8222432; DOI=10.1097/00003086-199311000-00039
Oreffo R.O.C., Marshall G.J., Kirchen M., Garcia C., Gallwitz W.E., Chavez J., Mundy G.R., Bonewald L.F.
Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption.
Clin. Orthop. Relat. Res. 296:229-241(1993)

Cross-references
Cell line collections ATCC; CRL-2085 - Discontinued
DSMZ; ACC-268
Cell line databases/resources CLDB; cl520
Ontologies CLO; CLO_0002127
Biological sample resources BioSample; SAMN03151903
BioSample; SAMN03471441
Other Wikidata; Q54799749
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number27