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Cellosaurus C-433 (CVCL_1969)

[Text version]
Cell line name C-433
Synonyms C433
Accession CVCL_1969
Resource Identification Initiative To cite this cell line use: C-433 (RRID:CVCL_1969)
Comments Problematic cell line: Contaminated. Shown to be a RD-ES derivative (DSMZ=ACC-268). Originally thought to originate from a 35 year old female patient with a benign giant cell tumor of the right distal tibia.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00395.
Population: Caucasian.
Doubling time: ~25-30 hours (DSMZ=ACC-268).
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 2 fusion (Ex7/Ex5) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2169 (RD-ES)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ATCC; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11
D2S133819
D3S135815
D5S81811
D7S82010
D8S117913
D13S31711
D16S53911
D18S5114,17.3
D19S43313,14
D21S1128
FGA25
Penta D9,12
Penta E11
TH017
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=8222432; DOI=10.1097/00003086-199311000-00039
Oreffo R.O.C., Marshall G.J., Kirchen M., Garcia C., Gallwitz W.E., Chavez J., Mundy G.R., Bonewald L.F.
Characterization of a cell line derived from a human giant cell tumor that stimulates osteoclastic bone resorption.
Clin. Orthop. Relat. Res. 296:229-241(1993)

Cross-references
Cell line collections (Providers) ATCC; CRL-2085 - Discontinued
DSMZ; ACC-268 - Discontinued
Cell line databases/resources CLO; CLO_0002127
CLDB; cl520
cancercelllines; CVCL_1969
DSMZCellDive; ACC-268
Biological sample resources BioSample; SAMN03151903
BioSample; SAMN03471441
Encyclopedic resources Wikidata; Q54799749
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number33