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Cellosaurus CHO-DXB11 (CVCL_1977)

[Text version]

Cell line name CHO-DXB11
Synonyms CHO DXB11; CHO-DUX-B11; CHO (Dux B11); CHO-DUK-XB11; DUK-XB11; CHO-DUKX B11; CHO-DUKXB11; DUKX-B11; DUX B11; DUXB11; DXB-11; DXB11; CHO-DUKX; DUKX-CHO; DUKX; CHO-DHFR -; CHO/dhFr-; CHO/dhfr-; CHO duk-; CHO B11; B11
Accession CVCL_1977
Secondary accession CVCL_9246
Resource Identification Initiative To cite this cell line use: CHO-DXB11 (RRID:CVCL_1977)
Comments Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9096.
Doubling time: ~20-24 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: Genome sequenced.
Omics: miRNA expression profiling.
Derived from sampling site: Ovary.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_5A23 (CHO-UKB25)
Children:
CVCL_6356 (35.6)CVCL_4J66 (3M)CVCL_5A28 (4-HS-MYC)
CVCL_6358 (5/9 m a3-18)CVCL_4586 (5A-HS-MYC)CVCL_5A29 (5B-HS-MYC)
CVCL_5A27 (6A-HS-MYC)CVCL_4582 (6E6 [Hamster mAB-producing])CVCL_JM03 (B11UVres)
CVCL_4583 (B13-24)CVCL_6339 (CHO 1-15 500)CVCL_B0CX (CHO 106.3 AM1)
CVCL_DC99 (CHO 1beta9, 12.5, clone 36)CVCL_B0CV (CHO 3-631-436 AM5)CVCL_B0CW (CHO 3-631-436 AM8)
CVCL_1Y13 (CHO 92UG21-9 gp120 (Clade D))CVCL_DD00 (CHO beta2(414)cl.32)CVCL_9V75 (CHO CD28)
CVCL_A0GD (CHO dhfr- Clone 20/1)CVCL_JZ93 (CHO dhfr(-) Bcl2)CVCL_JZ94 (CHO dhfr(-) E1B-19K)
CVCL_8844 (CHO DP-12)CVCL_1Y09 (CHO MW959 gp140 (Clade A))CVCL_IR13 (CHO-13D-35D)
CVCL_JZ95 (CHO-ADLE)CVCL_JZ96 (CHO-AFLE)CVCL_Y102 (CHO-betaGal)
CVCL_WS56 (CHO-p658-hPRL)CVCL_WS57 (CHO-pEDdc-hPRL)CVCL_X696 (CHO-SIVmac239 gp130 Clone 3)
CVCL_X695 (CHO-SIVsmH4 gp130 Clone AD5)CVCL_JX39 (CHO/dhFr-AC-free)CVCL_6384 (CTLA4 Ig-24)
CVCL_5A31 (F435)CVCL_3711 (HIIF-D)CVCL_4587 (LA 3-5)
CVCL_5I79 (ValiScreen human KCNA3)CVCL_DC12 (WCL2)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/Chinese_hamster_ovary_cell
Publications

PubMed=6933469; DOI=10.1073/pnas.77.7.4216
Urlaub G., Chasin L.A.
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
Proc. Natl. Acad. Sci. U.S.A. 77:4216-4220(1980)

PubMed=6287224; DOI=10.1128/MCB.2.1.93
Graf L.H. Jr., Chasin L.A.
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.
Mol. Cell. Biol. 2:93-96(1982)

PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014
Becker J., Hackl M., Rupp O., Jakobi T., Schneider J., Szczepanowski R., Bekel T., Borth N., Goesmann A., Grillari J., Kaltschmidt C., Noll T., Puhler A., Tauch A., Brinkrolf K.
Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.
J. Biotechnol. 156:227-235(2011)

DOI=10.3390/pr1030296
Wurm F.M.
CHO quasispecies -- implications for manufacturing processes.
Processes 1:296-311(2013)

PubMed=25887056; DOI=10.1186/s12864-015-1391-x
Kaas C.S., Kristensen C., Betenbaugh M.J., Andersen M.R.
Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy.
BMC Genomics 16:160.1-160.9(2015)

PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022
Klanert G., Jadhav V., Shanmukam V., Diendorfer A., Karbiener M., Scheideler M., Bort J.H., Grillari J., Hackl M., Borth N.
A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines.
J. Biotechnol. 235:150-161(2016)

DOI=10.3390/pr5020020
Wurm F.M., Wurm M.J.
Cloning of CHO cells, productivity and genetic stability -- a discussion.
Processes 5:20.1-20.13(2017)

PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002
Szeliova D., Ruckerbauer D.E., Galleguillos S.N., Petersen L.B., Natter K., Hanscho M., Troyer C., Causon T., Schoeny H., Christensen H.B., Lee D.-Y., Lewis N.E., Koellensperger G., Hann S., Nielsen L.K., Borth N., Zanghellini J.
What CHO is made of: variations in the biomass composition of Chinese hamster ovary cell lines.
Metab. Eng. 61:288-300(2020)

Cross-references
Cell line collections ATCC; CRL-9096
BCRC; 60133
BCRJ; 0068
CCTCC; GDC0117
DSMZ; ACC-126
ECACC; 94060607
KCB; KCB 200712YJ
NCBI_Iran; C590
Cell line databases/resources CLDB; cl728
CLDB; cl729
CLDB; cl1114
CCRID; 1101HAM-PUMC000003
CCRID; 1102HAM-NIFDC00096
CCRID; 3101HAMGNHa4
CCRID; 4201HAM-CCTCC00117
CCRID; 6101MOU-CERC000112
TOKU-E; 945
Ontologies CLO; CLO_0002429
CLO; CLO_0002460
CLO; CLO_0002849
Gene expression databases GEO; GSM1968579
GEO; GSM1968580
GEO; GSM1968585
GEO; GSM1968590
GEO; GSM1968586
GEO; GSM1968581
GEO; GSM1968582
GEO; GSM1968587
GEO; GSM1968583
GEO; GSM1968592
GEO; GSM1968584
GEO; GSM1968588
GEO; GSM1968573
GEO; GSM1968574
GEO; GSM1968577
GEO; GSM1968578
Other Wikidata; Q54812674
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number25