ID   CHO-DXB11
AC   CVCL_1977
AS   CVCL_9246
SY   CHO DXB11; DXB11-CHO; CHO-DUX-B11; CHO (Dux B11); CHO-DUK-XB11; DUK-XB11; CHO-DUKX B11; CHO-DUKXB11; DUKX-B11; DUX B11; DUXB11; DXB-11; DXB11; CHO-DUKX; DUKX-CHO; DUKX; CHO-DHFR -; CHO/dhFr-; CHO/dhfr-; CHO(dhfr-); CHO duk-; CHOd-; CHO B11; B11
DR   CLO; CLO_0002429
DR   CLO; CLO_0002460
DR   CLO; CLO_0002849
DR   CLDB; cl728
DR   CLDB; cl729
DR   CLDB; cl1114
DR   ATCC; CRL-9096
DR   BCRC; 60133
DR   BCRJ; 0068
DR   CCRID; 1101HAM-PUMC000003
DR   CCRID; 1102HAM-NIFDC00096
DR   CCRID; 3101HAMGNHa4
DR   CCRID; 4201HAM-CCTCC00117
DR   CCRID; 6101MOU-CERC000112
DR   CCTCC; GDC0117
DR   DSMZ; ACC-126
DR   DSMZCellDive; ACC-126
DR   ECACC; 94060607
DR   GEO; GSM1968579
DR   GEO; GSM1968580
DR   GEO; GSM1968585
DR   GEO; GSM1968590
DR   GEO; GSM1968586
DR   GEO; GSM1968581
DR   GEO; GSM1968582
DR   GEO; GSM1968587
DR   GEO; GSM1968583
DR   GEO; GSM1968592
DR   GEO; GSM1968584
DR   GEO; GSM1968588
DR   GEO; GSM1968573
DR   GEO; GSM1968574
DR   GEO; GSM1968577
DR   GEO; GSM1968578
DR   KCB; KCB 200712YJ
DR   NCBI_Iran; C590
DR   TOKU-E; 945
DR   Wikidata; Q54812674
RX   DOI=10.3390/pr1030296;
RX   DOI=10.3390/pr5020020;
RX   PubMed=6287224;
RX   PubMed=6933469;
RX   PubMed=19003404;
RX   PubMed=21945585;
RX   PubMed=25887056;
RX   PubMed=26993211;
RX   PubMed=32619503;
RX   PubMed=33596973;
RX   PubMed=34050613;
WW   https://en.wikipedia.org/wiki/Chinese_hamster_ovary_cell
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9096.
CC   Doubling time: ~20-24 hours (DSMZ=ACC-126).
CC   Omics: Genome sequenced.
CC   Omics: miRNA expression profiling.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_5A23 ! CHO-UKB25
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 31
//
RX   DOI=10.3390/pr1030296;
RA   Wurm F.M.;
RT   "CHO quasispecies -- implications for manufacturing processes.";
RL   Processes 1:296-311(2013).
//
RX   DOI=10.3390/pr5020020;
RA   Wurm F.M., Wurm M.J.;
RT   "Cloning of CHO cells, productivity and genetic stability -- a
RT   discussion.";
RL   Processes 5:20.1-20.13(2017).
//
RX   PubMed=6287224; DOI=10.1128/mcb.2.1.93-96.1982;
RA   Graf L.H. Jr., Chasin L.A.;
RT   "Direct demonstration of genetic alterations at the dihydrofolate
RT   reductase locus after gamma irradiation.";
RL   Mol. Cell. Biol. 2:93-96(1982).
//
RX   PubMed=6933469; DOI=10.1073/pnas.77.7.4216;
RA   Urlaub G., Chasin L.A.;
RT   "Isolation of Chinese hamster cell mutants deficient in dihydrofolate
RT   reductase activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:4216-4220(1980).
//
RX   PubMed=19003404; DOI=10.1023/A:1008052908496;
RA   Rasmussen B., Davis R., Thomas J., Reddy P.;
RT   "Isolation, characterization and recombinant protein expression in
RT   Veggie-CHO: a serum-free CHO host cell line.";
RL   Cytotechnology 28:31-42(1998).
//
RX   PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014;
RA   Becker J., Hackl M., Rupp O., Jakobi T., Schneider J.,
RA   Szczepanowski R., Bekel T., Borth N., Goesmann A., Grillari J.,
RA   Kaltschmidt C., Noll T., Puhler A., Tauch A., Brinkrolf K.;
RT   "Unraveling the Chinese hamster ovary cell line transcriptome by
RT   next-generation sequencing.";
RL   J. Biotechnol. 156:227-235(2011).
//
RX   PubMed=25887056; DOI=10.1186/s12864-015-1391-x;
RA   Kaas C.S., Kristensen C., Betenbaugh M.J., Andersen M.R.;
RT   "Sequencing the CHO DXB11 genome reveals regional variations in
RT   genomic stability and haploidy.";
RL   BMC Genomics 16:160.1-160.9(2015).
//
RX   PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022;
RA   Klanert G., Jadhav V., Shanmukam V., Diendorfer A.B., Karbiener M.,
RA   Scheideler M., Hernandez-Bort J.A., Grillari J., Hackl M., Borth N.;
RT   "A signature of 12 microRNAs is robustly associated with growth rate
RT   in a variety of CHO cell lines.";
RL   J. Biotechnol. 235:150-161(2016).
//
RX   PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002;
RA   Szeliova D., Ruckerbauer D.E., Galleguillos S.N., Petersen L.B.,
RA   Natter K., Hanscho M., Troyer C., Causon T., Schoeny H.,
RA   Christensen H.B., Lee D.-Y., Lewis N.E., Koellensperger G., Hann S.,
RA   Nielsen L.K., Borth N., Zanghellini J.;
RT   "What CHO is made of: variations in the biomass composition of Chinese
RT   hamster ovary cell lines.";
RL   Metab. Eng. 61:288-300(2020).
//
RX   PubMed=33596973; DOI=10.1186/s13039-021-00528-3;
RA   Turilova V.I., Goriachaia T.S., Yakovleva T.K.;
RT   "Chinese hamster ovary cell line DXB-11: chromosomal instability and
RT   karyotype heterogeneity.";
RL   Mol. Cytogenet. 14:11.1-11.12(2021).
//
RX   PubMed=34050613; DOI=10.1002/biot.202100165;
RA   Wurm M.J., Wurm F.M.;
RT   "Naming CHO cells for bio-manufacturing: genome plasticity and variant
RT   phenotypes of cell populations in bioreactors question the relevance
RT   of old names.";
RL   Biotechnol. J. 16:e2100165.1-e2100165.13(2021).
//